Gonadotropin pulsations across development
Gonadotropin pulsations across development
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DOI：
10.1159/000023165
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发表时间：
1998-01-01
期刊：
影响因子：
--
通讯作者：
Crowley, WF
中科院分区：
文献类型：
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作者：
Hayes, FJ;Crowley, WF
人类生殖轴的启动和维持取决于下丘脑的促性腺激素释放激素（GnRH）的脉冲式分泌。在人类中，追踪内源性GnRH分泌依赖于对促性腺激素的三种糖蛋白产物，促黄体生成素（LH）、促卵泡激素（FSH）和游离α-亚基（FAS）的频繁外周采样。在GnRH分泌迅速或垂体LH反应低的情况下，FAS作为GnRH分泌动力学的替代标志物上级LH。从新生儿时期的高水平，到儿童中期的静止期，然后是青春期开始时生殖轴的睡眠引起的重新激活，最终达到成年模式的脉动分泌，在男性中大约每2小时一次，在女性中随着月经周期的阶段而变化，这种间歇性的分泌模式允许反馈机制对GnRH神经元产生不同的影响，并通过允许频率和幅度在应激期间促进生殖轴的维持。调制
Initiation and maintenance of the reproductive axis in the human is contingent upon the pulsatile secretion of gonadotropin-releasing hormone (GnRH) from the hypothalamus. In man, tracking endogenous GnRH secretion relies on frequent peripheral sampling of three glycoprotein products of the gonadotrope, luteinizing hormone (LH), follicle-stimulating hormone (FSH) and free cr-subunit (FAS). FAS is superior to LH as a surrogate marker of GnRH secretory dynamics in those circumstances where GnRH secretion is rapid or where the pituitary LH response is low, The pattern of GnRH secretion is constantly changing across development; from high levels during the neonatal period, through a period of quiescence in mid-childhood, followed by sleep-entrained reactivation of the reproductive axis at the onset of puberty, ultimately culminating in the adult pattern of pulsatile secretion which in the male is approximately every 2 h and in the female varies with the stage of the menstrual cycle, This episodic mode of secretion allows differential impact of feedback mechanisms on the GnRH neurons and facilitates the maintenance of the reproductive axis during periods of stress by allowing frequency and amplitude modulations.