Potential mechanisms and implications for the formation of tau oligomeric strains.
Potential mechanisms and implications for the formation of tau oligomeric strains.
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DOI：
10.1080/10409238.2016.1226251
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发表时间：
2016
影响因子：
6.5
通讯作者：
Kayed R
中科院分区：
文献类型：
--
作者：
Gerson JE;Mudher A;Kayed R
多年来对 tau 蛋白聚集在神经退行性疾病中的毒性的研究不断深入，最终达成了这样的共识：可溶性寡聚形式的 tau 蛋白可能是疾病中毒性最强的实体。虽然 tau 蛋白病在 tau 蛋白病理学存在下有重叠，但每种疾病都有独特的症状和病理特征组合，然而，大多数 tau 蛋白研究都将 tau 蛋白寡聚体分组，并将它们作为同质群体进行研究。来自朊病毒领域的既定证据结合最新的 tau 蛋白和淀粉样蛋白研究表明，tau 蛋白是一种类似朊病毒的蛋白，能够在整个大脑中传播病理学。因此，tau 蛋白也可能形成朊病毒样菌株或不同的构象结构，这些构象结构可能因疾病而异，并且是神经退行性 tau 蛋白病症状和病理学差异的基础。因此，用于检测 tau 寡聚菌株的技术和新技术的发展可能会为神经退行性疾病带来更有效的诊断和治疗策略。
The culmination of many years of increasing research into the toxicity of tau aggregation in neurodegenerative disease has led to the consensus that soluble, oligomeric forms of tau are likely the most toxic entities in disease. While tauopathies overlap in the presence of tau pathology, each disease has a unique combination of symptoms and pathological features, however, most study into tau has grouped tau oligomers and studied them as a homogenous population. Established evidence from the prion field combined with the most recent tau and amyloidogenic protein research suggests that tau is a prion-like protein, capable of seeding the spread of pathology throughout the brain. Thus, it is likely that tau may also form prion-like strains or diverse conformational structures that may differ by disease and underlie some of the differences in symptoms and pathology in neurodegenerative tauopathies. The development of techniques and new technology for the detection of tau oligomeric strains may therefore lead to more efficacious diagnostic and treatment strategies for neurodegenerative disease.