Tp-e/QT ratio as an index of arrhythmogenesis
Tp-e/QT ratio as an index of arrhythmogenesis
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DOI：
10.1016/j.jelectrocard.2008.07.016
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发表时间：
2008-11-01
影响因子：
1.3
通讯作者：
Yan, Gan-Xin
中科院分区：
文献类型：
--
作者：
Gupta, Prasad;Patel, Chinmay;Yan, Gan-Xin
越来越多的基础和临床研究表明，心电图T波的峰末间期（Tp-e）可能对应于跨壁复极离散，Tp-e间期的扩大与恶性室性心律失常有关。本文综述了Tp-e间期和Tp-e/QT比值作为先天性和获得性离子通道疾病导致室性心律失常的心电图指标的应用。在健康个体中，心前区导联的Tp-e/QT比值的平均值约为0.21，并且在每分钟60至100次心跳的心率之间保持相对恒定。有趣的是，Tp-e/QT比值在有心肌梗死风险的患者中显著更大，如长QT综合征、Brugada综合征、短QT综合征患者，以及器质性心脏病患者，如急性心肌梗死患者。功能性折返是与Tp-e/QT比值增加相关的心肌梗死的潜在机制。(C)2008年爱思唯尔公司All rights reserved.
An increasing number of basic and clinical studies have suggested that the interval from the peak to the end of the electrocardiographic T wave (Tp-e) may correspond to the transmural dispersion of repolarization and that amplification of the Tp-e interval is associated with malignant ventricular arrhythmias. In this review, we outline the utility of the Tp-e interval and the Tp-e/QT ratio as an electrocardiographic index of arrhythmogenesis for both congenital and acquired ion channel disease leading to ventricular arrhythmias. In healthy individuals, the Tp-e/QT ratio has a mean value of approximately 0.21 in the precordial leads and it remains relatively constant between the heart rates from 60 to 100 beats per minute. Interestingly, the Tp-e/QT ratio is significantly greater in the patients at risk for arrhythinic event such as those with long QT syndrome, Brugada syndrome, short QT syndrome, and also in patients with organic heart disease such as acute myocardial infarction. Functional reentry is the underlying mechanism for arrhythmogenesis associated with an increased Tp-e/QT ratio. (C) 2008 Elsevier Inc. All rights reserved.