Clinical features, isolation, and complete genome sequence of severe acute respiratory syndrome coronavirus 2 from the first two patients in Vietnam
Clinical features, isolation, and complete genome sequence of severe acute respiratory syndrome coronavirus 2 from the first two patients in Vietnam
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DOI：
10.1002/jmv.26075
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发表时间：
2020-06-19
影响因子：
12.7
通讯作者：
Quang D Pham
中科院分区：
文献类型：
--
作者：
Lan T Phan;Thuong V Nguyen;Quang D Pham
2020年1月，我们在一个家族聚集性病例中发现了两名严重急性呼吸综合征冠状病毒2型（SARS-CoV-2）感染患者，其中一人来自中国武汉。从这些患者中分离的两株SARS-CoV-2全基因组序列与武汉分离株完全相同，相似性为99.98%。这在遗传学上暗示了SARS-CoV-2的人际传播，并表明武汉是越南早期爆发的最合理来源。年轻患者有轻度上呼吸道疾病和短暂的病毒脱落，而患有多种疾病的老年人有肺炎，长期病毒脱落和残留肺损伤。在病毒序列的ORF 1ab区域的非同义取代的证据值得进一步研究。
In January 2020, we identified two severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2)-infected patients in a familial cluster with one person coming from Wuhan, China. The complete genome sequences of two SARS-CoV-2 strains isolated from these patients were identical and 99.98% similar to strains isolated in Wuhan. This is genetically suggestive of human-to-human transmission of SARS-CoV-2 and indicates Wuhan as the most plausible origin of the early outbreak in Vietnam. The younger patient had a mild upper respiratory illness and a brief viral shedding, whereas the elderly with multi-morbidity had pneumonia, prolonged viral shedding, and residual lung damage. The evidence of nonsynonymous substitutions in the ORF1ab region of the viral sequence warrants further studies.