Effect of an adrenal inhibitor in hypertensive patients with suppressed renin.
Effect of an adrenal inhibitor in hypertensive patients with suppressed renin.
复制标题
肾上腺抑制剂对肾素抑制的高血压患者的作用。
作者：
J. Woods;G. Liddle;Edwin G. Stant;A. Michelakis;A. Brill
原发性高血压患者可根据血浆肾素值分为亚群。大约80%的人血浆肾素值正常或接近正常，而20%的人在直立姿势和钠消耗的双重刺激下具有明显低于正常的肾素值。在本研究中，9例患者抑制肾素活性进行了比较，5例正常的肾素值，寻找其他生理差异，可能揭示高血压状态的病理生理。高血压患者的抑制与非抑制的肾素活性在两个方面不同：他们有显着较高的交换钠值，他们响应肾上腺抑制剂，氨鲁米特，血压显着下降。从这项研究的结果可以推断，在血浆肾素活性受抑制的患者中，存在过量的某种未鉴定的盐皮质激素，或者即使是正常水平的醛固酮，
Patients with essential hypertension can be divided into subpopulations according to their plasma renin values. Approximately 80% have normal or near-normal plasma renin values while 20% have distinctly subnormal renin values in response to the double stimuli of upright posture and sodium depletion. In the present study, nine patients with suppressed renin activity were compared with five patients with normal renin values in search of other physiologic differences that might shed light on the pathophysiology of the hypertensive state. Hypertensive patients with suppressed renin activity differed from those with nonsuppressed renin activity in two respects: They had significantly higher exchangeable sodium values, and they responded to the adrenal inhibitor, aminoglutethimide, with significant decreases in blood pressure. From the results of this study one might infer either that some unidentified mineralocorticoid is present in excessive quantities in the patients with suppressed plasma renin activity or that even normal levels of aldosterone