Elastic Membrane Deformations Govern Interleaflet Coupling of Lipid-Ordered Domains.
Elastic Membrane Deformations Govern Interleaflet Coupling of Lipid-Ordered Domains.
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DOI：
10.1103/physrevlett.115.088101
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发表时间：
2015-08-21
影响因子：
8.6
通讯作者：
Akimov SA
中科院分区：
文献类型：
--
作者：
Galimzyanov TR;Molotkovsky RJ;Bozdaganyan ME;Cohen FS;Pohl P;Akimov SA
在两个膜小叶中负责区域注册的机制至今仍是谜。利用连续介质弹性理论，我们表明，通过将相对小叶的边缘相对移动几纳米，可以在较厚（有序）和较薄（无序）区域之间的边缘上实现最小的线张力。增加表面张力会导致线张力增加，从而导致更大的畴。由于结构域配准是由脂质变形能驱动的，因此它不需要特殊的脂质成分，也不需要膜中层的相互作用。
The mechanism responsible for domain registration in two membrane leaflets has thus far remained enigmatic. Using continuum elasticity theory, we show that minimum line tension is achieved along the rim between thicker (ordered) and thinner (disordered) domains by shifting the rims in opposing leaflets by a few nanometers relative to each other. Increasing surface tension yields an increase in line tension, resulting in larger domains. Because domain registration is driven by lipid deformation energy, it does not require special lipid components nor interactions at the membrane midplane.