Elevated platelet factor 4 and beta-thromboglobulin plasma levels in depressed patients with ischemic heart disease
Elevated platelet factor 4 and beta-thromboglobulin plasma levels in depressed patients with ischemic heart disease
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DOI：
10.1016/s0006-3223(96)00345-9
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发表时间：
1997-08-15
影响因子：
10.6
通讯作者：
Finkel, MS
中科院分区：
文献类型：
--
作者：
LaghrissiThode, F;Wagner, WR;Finkel, MS
临床抑郁症最近被认为是心肌梗死后患者心源性死亡的独立危险因素。这种死亡率增加的潜在机制仍不清楚。本研究探讨了缺血性心脏病（IHD）和抑郁症患者并发血小板活化异常导致血栓形成和增加血栓形成风险的假设。测定了年轻健康对照组、非抑郁症IHD患者和抑郁症IHD患者的血小板第4因子（PF4）和β-血小板球蛋白（β-TG）。IHD抑郁组的平均PF4和β-TG血浆水平显著高于对照组和IHD组。这种增加与年龄、性别、种族差异、阿司匹林使用或心脏病严重程度无关。这一发现表明，在患有IHD的抑郁症患者中，血小板活化程度更高，可能表明血栓并发症的风险增加。(C)1997年生物精神病学学会。
Clinical depression has recently been recognized as an independent risk factor for cardiac mortality in patients after myocardial infarction. The underlying mechanisms of this increased mortality remain unclear. This study investigated the hypothesis that patients suffering from ischemic heart disease (IHD) and depression concurrently may have abnormal platelet activation resulting in and increased risk of thrombosis. Platelet factor 4 (PF4) and beta-thromboglobulin (beta-TG) were measured in young healthy control subjects, in nondepressed patients with IHD, and in depressed patients with IHD. Mean PF4 and beta-TG plasma levels in the IHD group with depression were found to be significantly higher than those of the control and IHD groups. This increase was not related to age, gender, racial difference, aspirin use, or severity of cardiac disease. This finding suggests that in depressed patients with IHD there is greater platelet activation, and may indicate an increased risk of thrombotic complications. (C) 1997 Society of Biological Psychiatry.