Changes in ocular flow induced by hypo- and hypercapnia relate to static visual acuity in humans
Changes in ocular flow induced by hypo- and hypercapnia relate to static visual acuity in humans
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DOI：
10.04081/eye2011.e8
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发表时间：
2011-01-01
期刊：
影响因子：
0.3
通讯作者：
Someya, Nami
中科院分区：
文献类型：
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作者：
Hayashi, Naoyuki;Ikemura, Tsukasa;Someya, Nami
我们研究了低碳酸血症和高碳酸血症引起的眼血流量变化是否与静态视力有关。11例健康受试者（26 +/- 5岁）接受了3次治疗。采用三处理三阶段交叉设计。在低碳酸血症治疗（HYPO）中，受试者将每分钟通气量（V-E）控制在25 L/min的目标值，持续6 min。在高碳酸血症治疗（HYPER）中，受试者吸入高分数CO2气体（FICO 2 = 4%），持续6 min。在对照治疗（CON）中，V-E未被操纵。我们用激光散斑血流仪测量脉络膜和视网膜血流作为眼血流量，用Landolt C视力表测量静态视力。HYPER和CON（21 +/- 1。48 +/-1。和42 +/- 1 mmHg）。与对照组相比，HYPO组的视网膜血流量较基线显著降低（-22 +/-5%），但HYPER组的视网膜血流量显著增加（+3 +/-9%）。HYPO组的近视力显著低于对照组（0.21 +/-0.1 vs. 0.24 +/-0.1 P
We investigated whether the change in ocular blood flow, induced by hypo-and hypercapnia, is related to static visual acuity. Eleven healthy subjects (26 +/- 5 years) underwent three treatments. A three-treatment three-period crossover design was used. In the hypocapnia treatment (HYPO), the subjects controlled their minute ventilation (V-E) to a target of 25 L/min for 6 min. In the hypercapnia treatment (HYPER), the subjects inspired high-fraction CO2 gas (FICO2 = 4%) for 6 min. In the control treatment (CON), V-E was not manipulated. We measured choroidal and retinal blood flow by laser speckle flowmetry as ocular blood flow, and static visual acuity using the Landolt C chart End-tidal partial pressure of CO2 differed significantly among HYPO. HYPER and CON (21 +/- 1. 48 +/- 1. and 42 +/- 1 mmHg, respectively). Retinal blood flow decreased significantly from the baseline in HYPO (-22 +/- 5%), but increased significantly in HYPER (+3 +/- 9%) compared to CON. Decimal visual acuity was significantly lower in HYPO than in the CON (0.21 +/- 0.1 vs. 0.24 +/- 0.1 P