The effects of UVB plus calcipotriol on systemic calcium homeostasis in patients with chronic plaque psoriasis
The effects of UVB plus calcipotriol on systemic calcium homeostasis in patients with chronic plaque psoriasis
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UVB联合卡泊三醇对慢性斑块型银屑病患者全身钙稳态的影响
DOI：
10.1111/j.1365-2230.1997.tb01090.x
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发表时间：
1997
影响因子：
4.1
通讯作者：
P.E.H. Tchinson
中科院分区：
文献类型：
--
作者：
J. F. Burke;S. Iqbal;P.E.H. Tchinson
我们研究了在治疗慢性斑块型银屑病时，联合使用最大许可剂量的局部卡泊三醇和窄带短波紫外线 (TL01) 对全身钙稳态的影响。患者以开放方式随机接受单独使用 UVB、每周 UVB 加 100 g 卡泊三醇 (50 μg/g) 软膏或单独使用卡泊三醇软膏 (100 g/周)。除了接受联合治疗的组中血清磷酸盐略有增加（从0·92至1·22 mmol/l；P=0·046）外，组间或组内没有观察到差异。同时接受 UVB 和卡泊三醇治疗的患者的银屑病面积和严重程度评分 (PASI) 得到更大程度的改善 (P= 0·045)。 UVB 和卡泊三醇的组合是治疗慢性斑块型银屑病的安全有效的方法。
We studied the effects of combining topical calcipotriol, used at the maximal licensed dose, and narrow‐band short wave ultraviolet light (TL01) on systemic calcium homeostasis in the treatment of chronic plaque psoriasis. Patients were randomized in an open fashion to receive either UVB alone, UVB plus 100 g of calcipotriol (50 μg/g) ointment per week or calcipotriol ointment alone (100 g/week). With the exception of a slight increase in serum phosphate in the group receiving combination therapy (from 0·92 to 1·22 mmol/l; P= 0·046), no differences were observed between or within the groups. Psoriasis area and severity scores (PASI) improved to a greater extent in those patients receiving both UVB and calcipotriol (P= 0·045). The combination of UVB and calcipotriol is a safe, effective treatment for chronic plaque psoriasis.