Helping the helpers: polyamines help maintain helper T-cell lineage fidelity.
Helping the helpers: polyamines help maintain helper T-cell lineage fidelity.
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帮助助手：多胺有助于维持辅助性T细胞谱系的保真度。
DOI：
10.1097/in9.0000000000000002
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发表时间：
2022-07
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认识到多胺在免疫系统的调节和功能中起着关键作用，随着评估其作用所需的生物系统和分析工具的出现，多胺正在成为焦点。Puffy等人最近证明，多胺代谢在辅助性T细胞谱系确定中起核心作用，其通过产生翻译辅因子hypusinated eIF5A和通过适当的组蛋白乙酰化进行忠实的表观遗传调节。他们的发现增加了快速增长的数据，这些数据表明适当控制多胺代谢对正常运作的免疫系统至关重要。
The awareness that polyamines play a critical role in immune system regulation and function is coming into focus as the biological systems and analytical tools necessary to evaluate their roles have become available. Puleston et al have recently demonstrated that polyamine metabolism plays a central role in helper T-cell lineage determination through the production of the translational cofactor hypusinated eIF5A and faithful epigenetic regulation through proper histone acetylation. Their findings add to the rapidly growing body of data implicating properly controlled polyamine metabolism as essential for a normally functioning immune system.