Super-resolution in PET imaging
Super-resolution in PET imaging
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DOI：
10.1109/tmi.2005.861705
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发表时间：
2006-02-01
影响因子：
10.6
通讯作者：
Azhari, H
中科院分区：
文献类型：
--
作者：
Kennedy, JA;Israel, O;Azhari, H
本文介绍了一种用于提高临床正电子发射断层扫描（PET）扫描仪分辨率的超分辨率方法。通过将四个数据集与连续采集之间的空间偏移相结合并应用迭代算法获得超分辨率图像。使用临床PET/计算机断层扫描（CT）扫描仪（Discovery LS，GEMS）的二维和三维（3-D）采集模式获得体模的超分辨率衰减校正PET扫描。在一项患者研究中，在标准F-18 - FDG PET/CT扫描后，使用轴向移位在一个小病变周围进行超分辨率扫描，而不增加患者辐射暴露。在体模研究中，与不使用超分辨率方法（6 mm）相比，使用超分辨率方法可以轴向分辨较小的特征（3 mm）。超分辨率图像具有比原始图像更好的分辨率，并且在日冕图像和3-D采集横轴图像中提供更高的对比度。冠状超分辨率图像具有优越的上级的分辨率和对比度相比，图像重建，只是交错的数据，以适当的轴向位置。在患者研究中，超分辨率重建显示出更局部的F-18 - FDG摄取。一种新的方法，用于提高PET图像的分辨率，使用超分辨率的方法已经开发和实验证实，采用临床扫描仪。轴向分辨率的提高不需要改变硬件。
This paper demonstrates a super-resolution method for improving the resolution in clinical positron emission tomography (PET) scanners. Super-resolution images were obtained by combining four data sets with spatial shifts between consecutive acquisitions and applying an iterative algorithm, Super-resolution attenuation corrected PET scans of a phantom were obtained using the two-dimensional and three-dimensional (3-D) acquisition modes of a clinical PET/computed tomography (CT) scanner (Discovery LS, GEMS). In a patient study, following a standard F-18 - FDG PET/CT scan, a super-resolution scan around one small lesion was performed using axial shifts without increasing the patient radiation exposure. In the phantom study, smaller features (3 mm) could be resolved axially with the super-resolution method than without (6 mm). The super-resolution images had better resolution than the original images and provided higher contrast ratios in corohal images and in 3-D acquisition transaxial images. The coronal super-resolution images had superior resolution and contrast ratios compared to images reconstructed by merely interleaving the data to the proper axial location. In the patient study, super-resolution reconstructions displayed a more localized F-18 - FDG uptake. A new approach for improving the resolution of PET images using a super-resolution method has been developed and experimentally confirmed, employing a clinical scanner. The improvement in axial resolution requires no changes in hardware.