Etiological pathways of depressive and anxiety symptoms linked to personality traits: A genetically-informative longitudinal study
Etiological pathways of depressive and anxiety symptoms linked to personality traits: A genetically-informative longitudinal study
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与人格特质相关的抑郁和焦虑症状的病因学途径：一项遗传信息纵向研究
DOI：
10.1016/j.jad.2021.05.004
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发表时间：
2021
影响因子：
6.6
通讯作者：
J.
中科院分区：
文献类型：
--
作者：
Takahashi;Y.;Yamagata;S.;Ritchie;S. J.;Barker;E. D.;& Ando;J.
背景抑郁和焦虑的共病与长期不良心理健康状态的风险增加有关。然而，目前对它们的遗传和环境影响知之甚少，这有助于解释共病性和独特性。本研究使用纵向双生子数据，从Gray的强化敏感性理论（Reinforcement Sensitivity Theory，简称EEE）的角度探讨了抑郁和焦虑之间的重叠和不同关系：行为抑制和激活系统的两种人格特征方法对422对双生子进行BIS和BAS检查，（298个同卵和124个异卵对）通过在波1完成个性问卷和在波2完成情绪症状问卷参与。波平均2.23 years apart.ResultsMultivariate Cholesky分解表明，人格特质（BIS和BAS）的遗传方差解释了所有的抑郁和焦虑症状的遗传方差。此外，与BIS相关的遗传因素积极解释抑郁和焦虑症状，而与BAS相关的遗传因素消极解释抑郁症状。LimitationsLimitations包括较短的时间间隔和依赖自我报告的data.ConclusionsThe本研究提供了证据，解释抑郁和焦虑症状的重叠和分化，通过使用人格特质的纵向数据，基因信息设计研究结果表明，人格特质从格雷的抑郁模型中发挥了重要作用，并澄清了描述，抑郁和焦虑症状。
BackgroundThe comorbidity of depression and anxiety is associated with an increased risk of prolonged adverse mental health status. However, little is currently known about their genetic and environmental influences that help to explain both the comorbidity and distinctiveness. Using longitudinal twin data, the present study investigated both the overlapping and distinct relationships between depression and anxiety viewed from the perspective of Gray's Reinforcement Sensitivity Theory (RST): two personality traits of the Behavioral Inhibition and Activation Systems (BIS and BAS).MethodsA total of 422 twin pairs (298 monozygotic and 124 dizygotic pairs) participated by completing a personality questionnaire at wave 1, and mood symptoms questionnaires at wave 2. The waves were on average 2.23 years apart.ResultsMultivariate Cholesky decomposition indicated that the genetic variance of the personality traits (BIS and BAS) explained all of the genetic variance in depressive and anxiety symptoms. Additionally, genetic factors related to the BIS positively explained depressive and anxiety symptoms, whereas genetic factors related to the BAS negatively explained only depressive symptoms.LimitationsLimitations include shorter time interval and the reliance on self-reported data.ConclusionsThe present study provided evidence explaining the overlap and differentiation of depressive and anxiety symptoms by using data on personality traits in a longitudinal, genetically-informative design. The findings suggested the personality traits from Gray's RST model played an important role in the prediction, and clarified the description, of both depressive and anxiety symptoms.