Bleomycin-induced chromosome breaks as a risk marker for lung cancer: a case-control study with population and hospital controls.
Bleomycin-induced chromosome breaks as a risk marker for lung cancer: a case-control study with population and hospital controls.
复制标题
博来霉素诱导的染色体断裂作为肺癌的风险标记：一项针对人群和医院对照的病例对照研究。
DOI：
10.1093/carcin/24.2.269
复制
发表时间：
2003
期刊：
影响因子：
4.7
通讯作者：
Shields,PeterG
中科院分区：
文献类型：
--
作者：
Zheng,Yun-Ling;Loffredo,ChristopherA;Yu,Zhipeng;Jones,RaymondT;Krasna,MarkJ;Alberg,AnthonyJ;Yung,Rex;Perlmutter,Donna;Enewold,Lindsey;Harris,CurtisC;Shields,PeterG
环境中致癌物的暴露和个人的易感性在癌症风险中起着重要作用。通过量化诱变剂诱导的染色体断裂来测量的 DNA 修复能力欠佳，可能可以解释不同的宿主对环境致癌物的易感性。在一项正在进行的肺癌病例对照研究中，我们比较了 152 名非小细胞肺癌患者与 94 名人群对照和 85 名无癌症病史的医院对照患者对博来霉素诱导的染色体断裂的个体敏感性。诱变剂敏感性通过用博莱霉素处理的培养的外周血淋巴细胞中每个细胞的平均染色单体断裂数来测量。使用非参数检验和 χ2 检验来确定粗病例对照比较的统计显着性，然后使用逻辑回归来调整重要的协变量。病例中博莱霉素诱导的每个细胞断裂的平均数为 1.01，而医院对照为 0.86（P<0.01），群体对照为 0.89（P<0.01）。在群体对照中，>65 岁的人每个细胞的平均断裂次数为 1.01 次，≤65 岁的人为 0.81 次（P<0.01）。将博来霉素敏感性定义为 >0.84 个断裂/细胞（群体对照中的中位水平），67% 的病例对博莱霉素敏感，而医院对照中这一比例为 49% [调整后比值比 (OR) = 2.69，95% 置信区间 (CI) = 1.44, 5.04]，而群体对照中这一比例为 51%（调整后 OR = 2.18，95% CI = 1.13， 4.21）。我们的数据表明，在前 331 名受试者中，博来霉素诱导的染色体断裂数量增加与肺癌风险增加显着相关。
Environmental exposure to carcinogens and individual susceptibility play significant roles in cancer risk. Suboptimal DNA repair capability, measured by quantifying mutagen-induced chromosome breaks, might explain variable host susceptibility to environmental carcinogens. In an ongoing lung cancer case-control study, we compared individual sensitivity to bleomycin-induced chromosome breaks in 152 non-small cell lung cancer patients with 94 population controls and 85 hospital controls with no history of cancer. Mutagen sensitivity was measured by mean number of chromatid breaks per cell in cultured peripheral blood lymphocytes treated with bleomycin. Non-parametric tests and χ2tests were used to determine the statistical significance of the crude case-control comparisons, followed by logistic regression to adjust for important covariates. The mean number of bleomycin-induced breaks per cell was 1.01 for the cases compared with 0.86 for hospital controls (P< 0.01) and 0.89 for population controls (P< 0.01). The mean number of breaks per cell was 1.01 for those >65 years old and 0.81 for those ≤65 years old (P< 0.01) among population controls. Defining bleomycin sensitive as >0.84 break/cell (the median level in population controls), 67% of the cases were bleomycin sensitive compared with 49% of the hospital controls [adjusted odds ratio (OR) = 2.69, 95% confidence interval (CI) = 1.44, 5.04], and 51% of the population controls (adjusted OR = 2.18, 95% CI = 1.13, 4.21). Our data indicate that the increased number of bleomycin-induced chromosome breaks was significantly associated with an increased risk of lung cancer in the first 331 subjects.
登录
查看更多内容
诱变剂诱导的染色体损伤测定的评估者协议和实用性。
DOI：
--
发表时间：
2001
期刊：
Anticancer research.
影响因子：
--
作者：
McIntyre,LM;O'Briant,KC;McBride,CM;Bepler,G
通讯作者：
Bepler,G
着色性干皮病、科凯恩综合征、解旋酶和 DNA 修复：有什么关系？
影响因子：
64.5
作者：
E. Friedberg
通讯作者：
E. Friedberg
墨西哥裔美国人的肺癌、吸烟模式和诱变剂敏感性。
DOI：
--
发表时间：
1995
期刊：
Journal of the National Cancer Institute. Monographs.
影响因子：
--
作者：
Strom,SS;Wu,S;Sigurdson,AJ;Hsu,TC;Fueger,JJ;Lopez,J;Tee,PG;Spitz,MR
通讯作者：
Spitz,MR
在病例对照研究中，诱变剂敏感性表现出剂量-反应关系。
DOI：
--
发表时间：
1996
期刊：
Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology.
影响因子：
--
作者：
Wu,X;Hsu,TC;Spitz,MR
通讯作者：
Spitz,MR
诱变剂敏感性作为非裔美国人肺癌风险的生物标志物。
DOI：
--
发表时间：
1995
期刊：
Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology.
影响因子：
--
作者：
Spitz,MR;Hsu,TC;Wu,X;Fueger,JJ;Amos,CI;Roth,JA
通讯作者：
Roth,JA