Melatonin phase shifts human circadian rhythms in a placebo-controlled simulated night-work study.
Melatonin phase shifts human circadian rhythms in a placebo-controlled simulated night-work study.
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DOI：
10.1152/ajpregu.00135.2001
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发表时间：
2002-02
期刊：
影响因子：
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通讯作者：
K. Sharkey;C. Eastman
中科院分区：
文献类型：
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作者：
K. Sharkey;C. Eastman
几乎没有证据表明褪黑素在轮班工作或时差反应中会产生相移效应。这项研究测试了褪黑素是否可以在模拟的夜班方案中促进相移。受试者(n=32)在夜间工作前的下午/晚上睡觉(睡眠时间表提前7小时)。他们在八个下午/晚上睡眠中的前四个阶段之前服用褪黑素(0.5毫克或3.0毫克)或安慰剂，而此时褪黑素已被证明可以相位推进生物钟。在褪黑激素和体温的昼夜节律中，褪黑激素比安慰剂产生更大的相位进步。弱光褪黑素开始的平均时相推进(+/-SD)为1.7+/-1.2h(安慰剂)、3.0+/-1.1h(0.5 mg)和3.9+/-0.5h(3.0 mg)。一项昼夜适应的测量表明，只有服用褪黑素的受试者才能达到这一目标(服用3.0毫克褪黑素的受试者有73%，服用0.5毫克褪黑素的受试者有56%，服用安慰剂的受试者没有服用褪黑素)。褪黑素可以用来促进夜间工作和飞机旅行的适应。
There has been scant evidence for a phase-shifting effect of melatonin in shift-work or jet-lag protocols. This study tested whether melatonin can facilitate phase shifts in a simulated night-work protocol. Subjects (n = 32) slept in the afternoons/evenings before night work (a 7-h advance of the sleep schedule). They took melatonin (0.5 mg or 3.0 mg) or placebo before the first four of eight afternoon/evening sleep episodes at a time when melatonin has been shown to phase advance the circadian clock. Melatonin produced larger phase advances than placebo in the circadian rhythms of melatonin and temperature. Average phase advances (+/-SD) of the dim light melatonin onset were 1.7 +/- 1.2 h (placebo), 3.0 +/- 1.1 h (0.5 mg), and 3.9 +/- 0.5 h (3.0 mg). A measure of circadian adaptation, shifting the temperature minimum enough to occur within afternoon/evening sleep, showed that only subjects given melatonin achieved this goal (73% with 3.0 mg, 56% with 0.5 mg, and 0% with placebo). Melatonin could be used to promote adaptation to night work and jet travel.