EXPERIMENTAL CORTICOSTEROID OCULAR HYPERTENSION IN THE RABBIT

EXPERIMENTAL CORTICOSTEROID OCULAR HYPERTENSION IN THE RABBIT
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DOI：
10.1007/bf00407840
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发表时间：
1978-01-01
期刊：
ALBRECHT VON GRAEFES ARCHIV FUR KLINISCHE UND EXPERIMENTELLE OPHTHALMOLOGIE
影响因子：
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通讯作者：
TOMAZZOLI, L
TOMAZZOLI, L
中科院分区：
其他
文献类型：
--
作者：
BONOMI, L;PERFETTI, S;TOMAZZOLI, L

文献摘要

被引文献

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每周结膜下注射4 mg repository β-重复3周以上的米松可使96%的治疗兔的眼内压（IOP）持续升高。治疗通常耐受良好，仅在少数动物中存在重要的全身毒性作用。由此获得的高眼压是恒定的，重现性好，对抗青光眼药物敏感。该动物模型适用于药物降压效果的检测及高眼压、青光眼等疾病的研究。
Weekly subconjunctival injections of 4 mg repository .beta.-methasone, repeated over 3 wk, produced a sustained increase of intraocular pressure (IOP) in 96% of the treated rabbits. Treatment was generally well tolerated and important systemic toxic effects were present only in a few animals. The ocular hypertension so obtained was constant, well reproducible and sensitive to antiglaucoma drugs. This animal model should be suitable for testing the pressure-lowering effect of drugs and for other studies on ocular hypertension and glaucoma.