Inflammasomes as therapeutic targets in human diseases.
Inflammasomes as therapeutic targets in human diseases.
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炎症小体作为人类疾病的治疗靶点。
DOI：
10.1038/s41392-021-00650-z
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发表时间：
2021-07-02
影响因子：
39.3
通讯作者：
Song YH
中科院分区：
文献类型：
--
作者：
Li Y;Huang H;Liu B;Zhang Y;Pan X;Yu XY;Shen Z;Song YH
炎性小体是先天免疫系统的蛋白质复合物，其响应于外源性病原体或内源性危险信号而引发炎症。炎性体多蛋白复合物由三部分组成：传感器蛋白、衔接子和半胱天冬酶原-1。炎性体的激活导致半胱天冬酶-1的激活，半胱天冬酶-1裂解促炎细胞因子如IL-1β和IL-18，导致细胞凋亡。炎性体的效应子不仅提供针对感染性病原体的保护，而且介导对无菌损伤的控制。异常的炎性体信号传导与心血管和代谢疾病、癌症和神经退行性疾病的发展有关。在这里，我们回顾了炎性小体作为一把双刃剑在各种疾病中的作用，其结果可以是好的或坏的，这取决于疾病以及遗传背景。我们强调炎性记忆和两次激活过程。我们还提出了M型和N型炎症模型，并讨论了炎症体通路如何成为开发新疗法的靶点。
Inflammasomes are protein complexes of the innate immune system that initiate inflammation in response to either exogenous pathogens or endogenous danger signals. Inflammasome multiprotein complexes are composed of three parts: a sensor protein, an adaptor, and pro-caspase-1. Activation of the inflammasome leads to the activation of caspase-1, which cleaves pro-inflammatory cytokines such as IL-1β and IL-18, leading to pyroptosis. Effectors of the inflammasome not only provide protection against infectious pathogens, but also mediate control over sterile insults. Aberrant inflammasome signaling has been implicated in the development of cardiovascular and metabolic diseases, cancer, and neurodegenerative disorders. Here, we review the role of the inflammasome as a double-edged sword in various diseases, and the outcomes can be either good or bad depending on the disease, as well as the genetic background. We highlight inflammasome memory and the two-shot activation process. We also propose the M- and N-type inflammation model, and discuss how the inflammasome pathway may be targeted for the development of novel therapy.
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影响因子：
30.5
作者：
Buerckstuemmer, Tilmann;Baumann, Christoph;Superti-Furga, Giulio
通讯作者：
Superti-Furga, Giulio
影响因子：
6.1
作者：
Cintia Ferrari, Carina;Pott Godoy, Maria Clara;Juan Pitossi, Fernando
通讯作者：
Juan Pitossi, Fernando
影响因子：
5.3
作者：
Beyer, Marianna M. S.;Lonnemann, Niklas;Korte, Martin
通讯作者：
Korte, Martin
影响因子：
15.1
作者：
Alcocer-Gomez, Elisabet;de Miguel, Manuel;Cordero, Mario D.
通讯作者：
Cordero, Mario D.
影响因子：
5.1
作者：
Alcocer-Gomez, Elisabet;Ulecia-Moron, Cristina;Cordero, Mario D.
通讯作者：
Cordero, Mario D.