Early menopause does not influence left ventricular diastolic dysfunction: A clinical observational study in healthy subjects
Early menopause does not influence left ventricular diastolic dysfunction: A clinical observational study in healthy subjects
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DOI：
10.1016/j.jjcc.2015.11.014
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发表时间：
2016-11-01
影响因子：
2.5
通讯作者：
Komuro, Issei
中科院分区：
文献类型：
--
作者：
Hirokawa, Megumi;Daimon, Masao;Komuro, Issei
背景资料：左心室舒张功能障碍（LVDD）的患病率在50岁以后的女性中急剧增加，可能导致老年女性舒张性心力衰竭的高患病率。绝经后雌激素水平的下降被认为是造成这种现象的机制之一。然而，有一个缺乏的数据绝经的时间和LVDD的进展之间的关系在临床上设置，因此，我们调查了这种关系在健康的绝经后women.Methods：我们招募了115名妇女，并将其分为两组，根据绝经年龄中位数：61谁经历了绝经在50年（绝经后期组）。结果：两组患者左室舒张功能参数无显著性差异（二尖瓣E/A，p= 0.561; e '，p= 0.052; Ele'，p = 0.081; DCT，p= 0.082; LVDD分级的患病率，p = 0.801），以及两组之间的其他超声心动图参数和临床特征。多元线性回归分析显示，LVDD的独立决定因素是年龄和体重指数，但不是绝经的时间。结论：绝经早期并不影响绝经后妇女LVDD的进展。老年女性LVDD的急剧进展是复杂的，可能受到多种因素的影响。(C)2015年日本心脏病学院。由爱思唯尔有限公司出版。保留所有权利。
Background: The prevalence of left ventricular diastolic dysfunction (LVDD) sharply increases in women after their 50s and may contribute to the high prevalence of diastolic heart failure in elderly women. A decrease in estrogen levels after menopause is postulated to be one of the mechanisms responsible for this phenomenon. However, there is a paucity of data on the relationship between the timing of menopause and the progression of LVDD in the clinical setting; thus, we investigated this relationship in healthy postmenopausal women.Methods: We enrolled 115 women and divided them into two groups according to median menopause age: 61 who experienced menopause at 50 years (late menopause group). We compared the echocardiographic and clinical characteristics between the two groups.Results: There were no significant differences in LV diastolic parameters (mitral E/A, p= 0.561; e', p= 0.052; Ele', p = 0.081; DCT, p= 0.082; prevalence of LVDD class, p = 0.801), as well as other echocardiographic parameters and clinical characteristics between the two groups. Multivariate linear regression analysis showed that the independent determinants of LVDD were age and body mass index, but not the timing of menopause.Conclusions: Early menopause did not influence the progression of LVDD in postmenopausal women. The sharp progression of LVDD in elderly women is complex and probably influenced by multiple factors. (C) 2015 Japanese College of Cardiology. Published by Elsevier Ltd. All rights reserved.