Temporal activation patterns of lateralized cognitive and task control processes in the human brain
Temporal activation patterns of lateralized cognitive and task control processes in the human brain
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DOI：
10.1016/j.brainres.2008.02.031
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发表时间：
2008-04-18
期刊：
影响因子：
2.9
通讯作者：
Waberski, Till D.
中科院分区：
文献类型：
--
作者：
Gobbele, Ren;Lamberty, Kathrin;Waberski, Till D.
在最近一项使用相同单词刺激的功能磁共振成像研究中，我们证明了视觉处理过程中大脑活动的任务依赖性偏侧化，左半球激活字母决策，右半球激活视觉空间决策（Stephan, K.E., Marshall, J.C., Friston, K.J., Rowe, J.B., Ritzl, A., Zilles, K., Fink, G.R., 2003。人脑中的偏侧认知过程和偏侧任务控制。科学 301, 384-386）。为了探索这些侧化过程的时间动态，我们在这里使用相同的刺激记录了多通道事件相关电位（ERP）。使用电流源密度重建 (CDR) 分析 ERP 数据。对比这两项任务得出的 ERP 结果，源反卷积显示，在布罗卡区的字母决策过程中，200-250 毫秒期间的活动增强，而右后顶叶皮层 (PPC) 的视觉空间决策过程中，175-200 毫秒和 250-275 毫秒的活动增强。在这些激活之前，ERP 数据显示前扣带皮层 (ACC) 内的活动在 125-150 毫秒内启动，随后该区域在 400-425 毫秒内延迟激活。与我们之前的功能磁共振成像研究一致，当前的电生理学数据支持这样的观点，即侧化认知过程可能取决于任务要求而不是刺激特性。目前的结果扩展了我们之前的发现，因为它们允许深入了解这些横向过程的时间动态及其与任务控制过程的关系。 ERP 的时间反卷积表明布罗卡区早期参与字母处理和 PPC 参与视觉空间处理。此外，在这种差异激活之前和之后 ACC 的激活与之前的研究结果一致，表明该区域可能涉及认知控制。 (C) 2008 Elsevier B.V. 保留所有权利。
In a recent fMRI study with identical word stimuli we demonstrated task-dependent lateralization of brain activity during visual processing, with left-hemispheric activations for letter decisions and right-hemispheric activations for visuospatial decisions (Stephan, K.E., Marshall, J.C., Friston, K.J., Rowe, J.B., Ritzl, A., Zilles, K., Fink, G.R., 2003. Lateralized Cognitive Processes and Lateralized Task Control in the Human Brain. Science 301, 384-386). In order to explore the temporal dynamics of these lateralized processes we here recorded multichannel event-related potentials (ERPs) using the same stimuli. ERP data were analysed with current source density reconstruction (CDR). Contrasting the ERP results elicited by the two tasks, source deconvolution showed enhanced activity during letter decisions in Broca's area from 200-250 ins during letter decisions and during visuospatial decisions in the right posterior parietal cortex (PPC) from 175-200ms and 250-275 ms. Prior to these activations ERP data revealed an initiation of activity within the anterior cingulate cortex (ACC) from 125-150 ms followed by a late activation of this region from 400-425 ms. Consistent with our previous fMRI study the current electrophysiological data support the notion that lateralized cognitive processes may depend on task requirements rather than stimulus properties. The current results extend our previous findings as they allow insights into the temporal dynamics of these lateralized processes and their relations to task control processes. The temporal deconvolution of ERPs suggests an early differential involvement of Broca's area in letter-processing and of PPC during visuospatial processing. In addition, activation of ACC prior and after this differential activation is consistent with previous findings suggesting that this area may be involved in cognitive control. (C) 2008 Elsevier B.V. All rights reserved.