Relative roles of follicle-stimulating hormone and luteinizing hormone in the control of inhibin secretion in normal men.
Relative roles of follicle-stimulating hormone and luteinizing hormone in the control of inhibin secretion in normal men.
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卵泡刺激素和黄体生成素在正常男性抑制素分泌控制中的相对作用。
DOI：
10.1172/jci113693
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发表时间：
1988
期刊：
影响因子：
--
通讯作者：
Bremner,WJ
中科院分区：
文献类型：
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作者：
McLachlan,RI;Matsumoto,AM;Burger,HG;deKretser,DM;Bremner,WJ
糖蛋白激素抑制素是由睾丸的支持细胞在卵泡刺激素（FSH）的影响下产生的，并被认为反过来抑制FSH的分泌。黄体生成素（LH）在任何物种的抑制素分泌中都没有被认为具有重要的控制作用。为了确定FSH和LH在控制人类抑制素分泌中的相对作用，我们检查了选择性FSH和LH替代对内源性促性腺激素被睾酮(T)抑制的正常男性血清抑制素水平的影响。在3个月的对照期后，9名男性接受200 mg T，每周1次，持续3-9个月。在T治疗期间，血清LH和FSH水平明显受到抑制，血清抑制素水平下降到对照组的40%。在继续治疗的同时，用纯化的hFSH （n = 4）或hLH （n = 4）治疗3-5个月，分别将血清促性腺激素水平提高到正常范围的上限，并显著提高抑制素水平，分别达到控制值的64%和55%。高剂量人绒毛膜促性腺激素（n = 3）的生理上LH替代使血清抑制素水平恢复到控制值的63%。在任何情况下，抑制素水平都没有完全恢复到控制水平。综上所述，血清抑制素水平在促性腺激素抑制期间下降，FSH和LH治疗均能部分或大致恢复。推测FSH直接作用于支持细胞以增加抑制素分泌，而LH可能通过增加睾丸内T水平和/或其他因素起作用。图片
The glycoprotein hormone inhibin is produced by the Sertoli cells of the testis under the influence of follicle-stimulating hormone (FSH) and is postulated in turn to inhibit FSH secretion. Luteinizing hormone (LH) is not recognized to have an important role in the control of inhibin secretion in any species. To determine the relative roles of FSH and LH in the control of inhibin secretion in man, we examined the effects of selective FSH and LH replacement on serum inhibin levels in normal men whose endogenous gonadotropins were suppressed by testosterone (T). After a 3-mo control period, nine men received 200 mg T enanthate i.m. weekly for 3-9 mo. During T treatment, serum LH and FSH levels were markedly suppressed and serum inhibin levels fell to 40% of control values. While continuing T, 3-5 mo of treatment with purified hFSH (n = 4) or hLH (n = 4) increased the respective serum gonadotropin level into the upper normal range and significantly increased inhibin levels back to 64 and 55% of control values, respectively. Supraphysiological LH replacement with high doses of human chorionic gonadotropin (n = 3) returned serum inhibin levels to 63% of control values. In no case did inhibin levels return fully to control levels. In conclusion, serum inhibin levels fell during gonadotropin suppression and were partially and approximately equally restored by either FSH or LH treatment. FSH presumably acts directly on the Sertoli cell to increase inhibin secretion whereas LH may act via increases in intratesticular T levels and/or other factor(s).Images