Suppression of prolactin does not reduce infant care by parentally experienced male common marmosets (Callithrix jacchus)
Suppression of prolactin does not reduce infant care by parentally experienced male common marmosets (Callithrix jacchus)
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DOI：
10.1016/j.yhbeh.2005.12.009
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发表时间：
2006-05-01
影响因子：
3.5
通讯作者：
Keverne, EB
中科院分区：
文献类型：
--
作者：
Almond, REA;Brown, GR;Keverne, EB
已发现高水平的催乳素与多种类群中父亲关怀的表达相关。然而，在哺乳动物中，几乎没有实验证据表明催乳素与刺激或维持父亲照顾有因果关系。在这里，我们在婴儿出生后的前两周内抑制了家庭中经历过父亲经历的普通狨猴父亲的催乳素产生。使用卡麦角林（Dostinex：辉瑞）抑制循环催乳素水平，卡麦角林是一种长效多巴胺 (D-2) 激动剂，具有最小的行为副作用。采用受试者内设计来比较 5 位有父亲经历的父亲在连续两次分娩期间的行为和荷尔蒙数据。卡麦角林将所有父亲的催乳素降低到可以忽略不计的水平，而不影响睾酮、双氢睾酮和皮质醇，也没有不良副作用。然而，降低催乳素对大多数相关行为模式的表达没有显着影响。父亲般的关怀。其中包括婴儿携带、婴儿美容以及父亲捡回和拒绝婴儿的频率。唯一受影响的与婴儿相关的行为是父亲触摸、舔舐和检查婴儿的频率。我们注意到卡麦角林治疗期间这种行为略有增加。尽管对父亲的照顾缺乏影响，但卡麦角林确实对父亲的亲和/性行为产生了影响，因为在药物治疗期间，父亲针对配偶和从配偶那里接受的梳理行为显着增加。这项研究表明，经验丰富的雄性狨猴在婴儿出生后通常没有高催乳素水平的情况下也能表现出父亲的行为。 (c) 2006 Elsevier Inc. 保留所有权利。
High levels of prolactin have been found to correlate with the expression of paternal care in a variety of taxa. However, in mammals, there is little experimental evidence that prolactin is causally involved in the stimulation or maintenance of paternal care. Here, we suppressed prolactin production in paternally experienced common marmoset fathers in their family groups during the first 2 weeks after their infants were born. Circulating prolactin levels were suppressed using cabergoline (Dostinex: Pfizer), a long acting dopamine (D-2) agonist with minimal behavioural side-effects. A within-subject design was used to compare behavioural and hormonal data on 5 paternally experienced fathers during two consecutive births. Cabergoline reduced prolactin to negligible levels in all fathers without effecting testosterone, DHT and cortisol and without adverse side-effects. However, lowering prolactin had no significant effect on the expression of majority of the behaviour patterns associated with. paternal care. These included infant carrying, infant grooming and the frequency with which fathers retrieved and rejected infants. The only infantrelated behaviour to be affected was the frequency with which fathers touched, licked and investigated infants. We noted a marginally significant increase in this behaviour during cabergoline treatment. Despite the lack of effect on paternal care, cabergoline did exert an effect on the affiliative/sexual behaviour of fathers as there was a significant increase in the grooming behaviour fathers directed at and received from their mates during drug treatment. This study showed that experienced male marmosets can express paternal behaviour in the absence of the high prolactin levels normally seen after infants are born. (c) 2006 Elsevier Inc. All rights reserved.