Interface tissue engineering and the formulation of multiple-tissue systems
Interface tissue engineering and the formulation of multiple-tissue systems
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DOI：
10.1007/b138509
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发表时间：
2006-01-01
期刊：
影响因子：
--
通讯作者：
Jiang, Jie
中科院分区：
文献类型：
--
作者：
Lu, Helen H.;Jiang, Jie
界面组织工程是一个令人兴奋的领域，其重点是开发能够促进不同类型组织之间以及植入物与周围组织之间整合的组织工程移植物。以界面组织工程为重点，并以前交叉韧带与骨之间的插入部位为例，本章讨论了软组织与骨整合的策略以及当前组织工程在这一领域的努力。这篇综述从这个问题的临床意义开始，然后是对现有固定方法的回顾，以及旨在解决这个关键问题的组织工程努力。将介绍用于替代多种组织的多阶段支架的开发，以及新型的体外共培养系统。在界面组织工程领域的未来发展方向也将进行讨论。
Interface tissue engineering is an exciting field which focuses on the development of tissue engineered grafts capable of promoting integration between different types of tissue and between the implant and surrounding tissue. Focusing on interface tissue engineering, and using the insertion site between the anterior cruciate ligament and bone as an example, this chapter discusses strategies in soft tissue to bone integration as well as current tissue engineering efforts in this area. This review begins with the clinical significance of this problem, followed by a review of existing fixation methods, and tissue engineering efforts aimed at addressing this critical issue. The development of multi-phased scaffolds designed for the replacement of more than one type of tissue, as well as novel in vitro co-culture systems will be introduced. Future directions in the field of interface tissue engineering will also be discussed.