METABOLIC IMMUNODEPRESSION AND METABOLIC IMMUNOTHERAPY - AN ATTEMPT OF IMPROVEMENT IN IMMUNOLOGICAL RESPONSE IN BREAST-CANCER PATIENTS BY CORRECTION OF METABOLIC DISTURBANCES
METABOLIC IMMUNODEPRESSION AND METABOLIC IMMUNOTHERAPY - AN ATTEMPT OF IMPROVEMENT IN IMMUNOLOGICAL RESPONSE IN BREAST-CANCER PATIENTS BY CORRECTION OF METABOLIC DISTURBANCES
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DOI：
10.1159/000225596
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发表时间：
1982-01-01
期刊：
影响因子：
3.5
通讯作者：
NIKIFOROV, YF
中科院分区：
文献类型：
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作者：
DILMAN, VM;BERSTEIN, LM;NIKIFOROV, YF
对32例接受根治性乳房切除术并患有激素代谢紊乱（包括免疫反应下降）的乳腺癌患者给予苯妥英钠和氯贝丁酯的效果进行了研究。在2-7个月内使用这些药物治疗。结果代谢指标改善，对DNCB、结核菌素和念珠菌素的迟发超敏反应（75.5%），T淋巴细胞计数升高（56.3%），淋巴细胞转化反应改善（66.6%）。停药后6-8 wk，免疫功能持续改善，4-6 mo，免疫应答逐渐下降，恢复到原来水平。停药后，停药后6-8周，氯贝特对代谢和免疫指标的影响不明显。代谢性免疫抑制是在正常衰老和肿瘤过程中逐渐发展起来的，消除代谢性免疫抑制应是代谢性免疫治疗的主要目标。为此，可以使用除苯丙氨酸和氯贝特以外的治疗手段，只要它们对碳水化合物-脂肪代谢发挥相同的作用。讨论了研究这种药物的长期疗程对癌症患者治疗的影响的可取性。
The effects of administration of phenformin and clofibrate to 32 breast cancer patients who underwent radical mastectomy and suffered from hormonal metabolic disturbances involving a decline in immunologic response were investigated. Treatment with these drugs during 2-7 mo. results in an improvement in metabolic parameters and delayed hypersensitivity reaction to DNCB [dinitrochlorobenzene], tuberculin and candidin (75.5% of cases), an increase in T lymphocyte count (56.3%) and an improvement of the reaction of lymphocyte blast transformation (66.6%). The improvement in the immunologic status of the patients persisted for 6-8 wk after the stoppage of phenformin administration; a gradual decline in immunologic response and return to the original level were recorded 4-6 mo. after stoppage of phenformin therapy. The effect of clofibrate on metabolic and immunologic parameters did not manifest itself as soon as 6-8 wk after stoppage. Elimination of metabolic immunodepression, which gradually develops in the course of normal aging and tumor process, should be the main objective of metabolic immunotherapy. To this end, therapeutic means, other than phenformin and clofibrate, may be used provided they exert the same effects on carbohydrate-fat metabolism. The desirability of studying of the effects of a long-term course of drugs of this kind on the therapy of cancer patients is discussed.