An Implantable Centrifugal Blood Pump for Long Term Circulatory Support
An Implantable Centrifugal Blood Pump for Long Term Circulatory Support
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用于长期循环支持的植入式离心血泵
DOI：
10.1097/00002480-199709000-00072
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发表时间：
1997
期刊：
影响因子：
4.2
通讯作者：
B. Griffith
中科院分区：
文献类型：
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作者：
K. Yamazaki;P. Litwak;R. Kormos;Toshio Mori;O. Tagusari;J. Antaki;M. Kameneva;M. Watach;L. Gordon;M. Umezu;J. Tomioka;B. Griffith
研制了一种紧凑型离心血泵作为植入式左心室辅助系统。叶轮直径为40 mm，泵尺寸为55 X 64 mm。第一个原型由钛合金制成，包括无刷直流电机在内的泵重量为400 g。第二个原型泵的重量减少到280 g。整个血液接触表面涂有类金刚石碳，以改善血液相容性。在2,500 rpm转速下，测量到超过7 L/min的流速和100 mmHg的压力，总功耗为9 W。一个新设计的带有再循环清洗系统的机械密封（“冷却密封”）被用作轴封。在该密封系统中，密封温度保持在40°C以下，以防止血液蛋白的热变性。冷却液还冷却泵电机线圈和轴颈轴承。清洗液通过超滤过滤器持续净化和灭菌，超滤过滤器安装在辅助驱动器控制台中。牛血的体外实验证明了可接受的低溶血率（标准化溶血指数= 0.005 ± 0.002 g/100 L）。目前正在使用小牛进行体内实验。通过左胸廓切开术，使用PTFE（Polyurethane）血管移植物进行左心室心尖-降主动脉旁路术，将泵放置在左胸腔内。在两个体内实验中，泵流速保持在5-8 L/min，泵功耗保持稳定在9-10 W。测量所有血浆游离血红蛋白水平
A compact centrifugal blood pump was developed as an implantable left ventricular assist system. The impeller diameter is 40 mm and the pump dimensions are 55 X 64 mm. This first prototype was fabricated from titanium alloy, resulting in a pump weight of 400 g including a brushless DC motor. Weight of the second prototype pump was reduced to 280 g. The entire blood contacting surface is coated with diamond like carbon to improve blood compatibility. Flow rates of over 7 L/min against 100 mmHg pressure at 2,500 rpm with 9 W total power consumption have been measured. A newly designed mechanical seal with a recirculating purge system (“Cool-Seal”) is used as a shaft seal. In this seal system, seal temperature is kept under 40°C to prevent heat denaturation of blood proteins. Purge fluid also cools the pump motor coil and journal bearing. The purge fluid is continuously purified and sterilized by an ultrafiltration filter incorporated into the paracorporeal drive console. In vitro experiments with bovine blood demonstrated an acceptably low hemolysis rate (normalized index of hemolysis = 0.005 ± 0.002 g/100 L). In vivo experiments are currently ongoing using calves. Via left thoracotomy, left ventricular apex-descending aorta bypass was performed utilizing a PTFE (Polytetrafluoroethylene) vascular graft, with the pump placed in the left thoracic cavity. In two in vivo experiments, pump flow rate was maintained at 5–8 L/min, and pump power consumption remained stable at 9–10 W. All plasma free hemoglobin levels were measured