Potassium channels
Potassium channels
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DOI：
10.1109/tnb.2004.842466
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发表时间：
2005-03
影响因子：
3.9
通讯作者：
S. Korn;Josef G. Trapani
中科院分区：
文献类型：
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作者：
S. Korn;Josef G. Trapani
钾通道是选择性跨膜转运K/sup +/的膜蛋白。它们存在于所有哺乳动物细胞中，并在可兴奋和不可兴奋细胞中发挥多种作用。完成其各种作用所需的表型多样性是由电导、不同门控事件的时程和机制以及通道与各种辅助蛋白的相互作用的差异产生的。通过生物物理、分子、结构和理论研究的整合，在理解K/sup +/通道功能的结构基础以及与K/sup +/通道功能障碍相关的疾病方面取得了重大进展。
Potassium channels are integral membrane proteins that selectively transport K/sup +/ across the cell membrane. They are present in all mammalian cells and have a wide variety of roles in both excitable and nonexcitable cells. The phenotypic diversity required to accomplish their various roles is created by differences in conductance, the timecourse and mechanisms of different gating events, and the interaction of channels with a variety of accessory proteins. Through the integration of biophysical, molecular, structural, and theoretical studies, significant progress has been made toward understanding the structural basis of K/sup +/ channel function, and diseases associated with K/sup +/ channel dysfunction.