A nicotinic hypothesis for Covid-19 with preventive and therapeutic implications
A nicotinic hypothesis for Covid-19 with preventive and therapeutic implications
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DOI：
10.5802/crbiol.8
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发表时间：
2020-01-01
影响因子：
2
通讯作者：
Miyara, Makoto
中科院分区：
文献类型：
--
作者：
Changeux, Jean-Pierre;Amoura, Zahir;Miyara, Makoto
SARS-CoV-2流行病在全球范围内提出了相当大的公共卫生问题。迫切需要根据现有的科学知识找到治疗方法。因此，我们试探性地提出了一个假设，希望最终能帮助挽救生命。根据目前的科学文献和新的流行病学数据，表明目前的吸烟状况似乎是预防SARS-CoV-2感染的保护因素[1]。我们假设烟碱乙酰胆碱受体（nAChR）在Covid-19感染的病理生理学中起关键作用，并可能成为预防和控制Covid-19感染的靶点。
SARS-CoV-2 epidemics raises a considerable issue of public health at the planetary scale. There is a pressing urgency to find treatments based upon currently available scientific knowledge. Therefore, we tentatively propose a hypothesis which hopefully might ultimately help save lives. Based on the current scientific literature and on new epidemiological data which reveal that current smoking status appears to be a protective factor against the infection by SARS-CoV-2 [1]. we hypothesize that the nicotinic acetylcholine receptor (nAChR) plays a key role in the pathophysiology of Covid-19 infection and might represent a target for the prevention and control of Covid-19 infection.