Three-dimensional modeling of middle ear biomechanics and its applications
Three-dimensional modeling of middle ear biomechanics and its applications
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DOI：
10.1097/00129492-200205000-00008
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发表时间：
2002-05-01
影响因子：
2.1
通讯作者：
Dormer, KJ
中科院分区：
文献类型：
--
作者：
Gan, RZ;Sun, QL;Dormer, KJ
假设：本研究探讨了是否可以使用有限元（FE）分析和三维重建的人类颞骨相结合的技术来构建一个计算模型，用于描述正常和病理中耳soundcondition.Background：生物系统的有限元模型已被用于耳生物力学。三维重建也已完成，但没有结合有限元建模和激光干涉测量的人颞骨。此外，有限元模型的人中耳及其听骨附件还没有报告的基础上，颞骨组织切片和形态重建，据作者所知。由于中耳的大小，变异性和复杂性，准确的形态数据和边界条件是必要的准确FE model.Methods：新鲜颞骨脱钙，包埋在火棉胶，切片和染色，扫描，数字化，和正常中耳重建。组织切片用于构建以韧带、肌肉和肌腱为边界条件的计算机辅助设计模型。由此获得的数据被转换成一个FE力学模型，该模型通过与17个新鲜人颞骨上的激光多普勒干涉测量获得的位移进行比较来验证。结果：生成了一个FE模型，展示了适度近似于人颞骨在鼓膜处接收90 dB声压级听觉频率的激光干涉测量数据的动态行为。精确的有限元建模，结合形态测量和干涉性能数据，预测正常和病理的人类听骨链的机械性能。
Hypothesis: This study investigated whether combined technologies of finite clement (FE) analysis and three-dimensional reconstruction of human temporal bones could be used to construct a computational model, useful in describing normal and pathologic middle ear sound conduction.Background: FE models for biologic systems have been used in ear biomechanics. Three-dimensional reconstructions have also been made, but not in combination with FE modeling and laser interferometry measuring of human temporal bones, Furthermore, an FE model for the human middle ear with its ossicular attachments has not been reported on the basis of temporal bone histologic sections and morphometric reconstruction, to the authors' best knowledge. Because of the size, variability, and complexity of the middle ear, accurate morphologic data and boundary conditions are necessary for accurate FE modeling.Methods: A fresh temporal bone was decalcified, embedded in celloidin, sectioned and stained, scanned, and digitized, and the normal middle ear was reconstructed. The histologic sections were used to construct a computer-aided design model with ligaments, muscles, and tendons as boundary conditions. The data thus obtained were converted into an FE mechanical model that was validated by comparison with displacements obtained by laser Doppler interferometry on 17 fresh human temporal bones.Results: An FE model was generated, demonstrating dynamic behavior that moderately approximated the laser interferometric data from human temporal bones receiving 90-dB sound pressure level auditory frequencies at the tympanic membrane.Conclusion: Accurate FE modeling, incorporating both morphometric and interferometric performance data, predicted both normal and pathologic mechanical performance of the human ossicular chain.