Predisposition for primary hyperlipidemia in Miniature Schnauzers and Shetland sheepdogs as compared to other canine breeds
Predisposition for primary hyperlipidemia in Miniature Schnauzers and Shetland sheepdogs as compared to other canine breeds
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DOI：
10.1016/j.rvsc.2009.12.003
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发表时间：
2010-06-01
影响因子：
2.4
通讯作者：
Arai, T.
中科院分区：
文献类型：
--
作者：
Mori, N.;Lee, P.;Arai, T.
迷你雪纳瑞是第一个犬种，在美国，据报道患有原发性高脂血症，但这还没有在其他地区记录。本研究使用从日本7个不同兽医诊所收集的900多只犬血浆样本，旨在比较日本小型雪纳瑞和其他纯种雪纳瑞之间的血浆甘油三酯（TG）和胆固醇浓度。此外，我们还研究了年龄和性别对纯种犬高脂血症发病率变化的影响。我们的研究结果表明，无论是小型雪纳瑞和设得兰群岛牧羊犬在日本表现出显着高浓度的血浆TO和总胆固醇，这被认为是高脂血症的迹象，与其他纯种和混合（杂种）犬品种。有趣的是，小型雪纳瑞犬和设得兰群岛牧羊犬原发性高脂血症的原因和状况可能不同，高胆固醇血症主要发生在小型雪纳瑞犬中，而高胆固醇血症发生在设得兰群岛牧羊犬中。但随着年龄的增长，两组的高脂血症均向高胆固醇血症和高甘油三酯血症发展，说明高脂血症的严重程度与年龄呈正相关。在严重程度方面也观察到性别差异。事实上，女性迷你雪纳瑞的严重程度高于男性，而设得兰群岛牧羊犬的性别之间更为平衡。(C)2009爱思唯尔有限公司版权所有。
Miniature Schnauzers are the first canine breed, in the United States, reported to suffer from primary hyperlipidemia, but this has yet to be documented in other regions. Using over 900 canine plasma samples collected from over seven different veterinary clinics across Japan, the aim of this study was to compare plasma triglyceride (TG) and cholesterol concentrations between Miniature Schnauzers and other purebreeds in Japan. In addition, we investigated the influence of aging and sex on changes to hyperlipidemia incidence in purebred dogs. Our results indicated that both Miniature Schnauzers and Shetland sheepdogs in Japan exhibited remarkably high concentrations of plasma TO and total cholesterol, which are considered to be signs of hyperlipidemia, as compared to other purebred and mixed (Mongrel) canine breeds. Interestingly, the cause and conditions of primary hyperlipidemia in Miniature Schnauzers and Shetland sheepdogs might be different, with hypertriglyceridemia predominantly occurring with Miniature Schnauzers and hypercholesterolemia occurring in Shetland sheepdogs. However, with the influence of aging, the hyperlipidemia evolves into both hypercholesterolemia and hypertriglyceridemia in both groups indicating that the severity of hyperlipidemia positively correlates with aging. Gender differences were also observed with regards to severity. In fact, a higher severity was prevalent with female Miniature Schnauzers than their male counterparts whereas it was more balanced between genders for Shetland sheepdogs. (C) 2009 Elsevier Ltd. All rights reserved.