Isolation, molecular characterization, immunological and anticoagulatant activities of polysaccharides from frankincense and its vinegar processed product
Isolation, molecular characterization, immunological and anticoagulatant activities of polysaccharides from frankincense and its vinegar processed product
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DOI：
10.1016/j.foodchem.2022.133067
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发表时间：
2022-04-28
期刊：
影响因子：
8.8
通讯作者：
Liu, Xiao-qiu
中科院分区：
文献类型：
--
作者：
Guo, Jing-yan;Song, Xin-ru;Liu, Xiao-qiu
乳香（FRA）是由精油、乳香酸（BAs）和多糖组成的油性树脂，已被用于改善血液循环和缓解痈痛。根据中医理论，醋加工的乳香（VPF）可以增加活血循环和缓解疼痛的效果。现有的研究对生物碱和精油进行了大量的研究。然而，从FRA和VPF中提取多糖的比较分析尚未见报道。本文分别从FRA和VPF中分离纯化了两种多糖，并对其结构和理化性质进行了分析。分别在RAW 264.7细胞和Sprague-Dawley大鼠体内检测四种多糖的免疫和抗凝血活性。从VPF中纯化的多糖具有较好的免疫和抗凝血活性。因此，多糖可能是VPF协同作用的活性物质之一。
Frankincense (FRA), the oily resin consisting of essential oils, boswellic acids (BAs) and polysaccharides, has been used to improve the blood circulation and relieve pain against carbuncles. According to the theory of traditional Chinese medicine, vinegar processed frankincense (VPF) can increase the effects of promoting blood circulation and relieving pain. Existing studies have carried out much on BAs and essential oils. However, the comparative analysis of polysaccharides from FRA and VPF has not been reported. In this paper, two polysaccharides were isolated and purified from FRA and the other two were from VPF, and their structures and physicochemical properties were analyzed. The immunological and anticoagulatant activities of the four polysaccharides were tested in RAW 264.7 cell and Sprague-Dawley rats, respectively. The polysaccharides purified from VPF showed better immunological and anticoagulatant activities than those in FRA. Therefore, polysaccharides may be one of the active substances for the synergistic effect of VPF.