Risk Factors Associated with Congenital Syphilis, Georgia, 2008-2015.
Risk Factors Associated with Congenital Syphilis, Georgia, 2008-2015.
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DOI：
10.1155/2023/3958406
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发表时间：
2023
影响因子：
--
通讯作者：
Hitti, Jane
中科院分区：
文献类型：
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作者：
Kachikis, Alisa;Schiff, Melissa A;Moore, Kathryn;Chapple-McGruder, Theresa;Arluck, Jessica;Hitti, Jane
先天性梅毒（CS）与围产期发病率和死亡率显著相关。本研究的目的是比较妊娠导致和未导致CS病例的梅毒感染妇女的危险因素，并评估居住县的其他地理和社会经济特征，作为衡量医疗不平等的指标。 这项研究将2008-2015年格鲁吉亚公共卫生部（DPH）的孕产妇和先天性梅毒数据联系起来。遵循加强流行病学观察性研究报告（STROBE）指南。人口，行为和病例特征进行了比较，梅毒感染的妇女谁没有与CS的婴儿。使用STATA 14.2（学院站，TX）进行卡方、Fisher精确和多变量回归分析。 在505名梅毒感染的妇女中，23%的婴儿患有CS，而77%没有。调整人种/种族后，与CS结局相关的因素为年龄大于35岁（调整的比值比（aOR）3.88; 95%置信区间（CI）1.01-14.89），医院/急诊科诊断梅毒（aOR 3.43; 95% CI 1.54-7.62）和高危行为如以性换取金钱或毒品（aOR 3.25; 95% CI 1.18-8.98）。居住县的特征和CS结果之间没有关联。 这项研究强调了可能与CS发病率相关的危险因素以及与CS相关的不良妊娠结局。需要进一步的工作来研究改进的数据收集系统，与CS相关的因素以及美国的预防措施。
Congenital syphilis (CS) is associated with significant perinatal morbidity and mortality. The study objectives were to compare risk factors among women with syphilis infection whose pregnancies did and did not result in CS cases and to evaluate other geographic and socioeconomic characteristics of county of residence as a measure of healthcare inequity. This study linked maternal and congenital syphilis data from the Georgia Department of Public Health (DPH), 2008-2015. The Strengthening the Reporting of Observational Studies in Epidemiology (STROBE) reporting guideline was followed. Demographic, behavioral, and case characteristics were compared among women with syphilis infection who did and did not have an infant with CS. Chi-square, Fisher's exact, and multivariate regression analyses were performed using STATA 14.2 (College Station, TX). Of 505 women with syphilis infection, 23% had an infant with CS, while 77% did not. After adjusting for race/ethnicity, factors associated with CS outcome were age greater than 35 years (adjusted odds ratio (aOR) 3.88; 95% confidence interval (CI) 1.01-14.89), hospital/emergency department diagnosis of syphilis (aOR 3.43; 95% CI 1.54-7.62), and high-risk behaviors such as exchanging sex for money or drugs (aOR 3.25; 95% CI 1.18-8.98). There were no associations between characteristics of county of residence and CS outcome. This study highlights risk factors that may be associated with CS incidence and the adverse pregnancy outcomes associated with CS. Further work is needed to study improved data collection systems, contributing factors related to CS as well as prevention measures in the United States.