Staging and prognosis of oropharyngeal carcinoma according to the 8th Edition of the American Joint Committee on Cancer Staging Manual in human papillomavirus infection
Staging and prognosis of oropharyngeal carcinoma according to the 8th Edition of the American Joint Committee on Cancer Staging Manual in human papillomavirus infection
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DOI：
10.1007/s00405-018-05263-x
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发表时间：
2019-03-01
影响因子：
2.6
通讯作者：
Ganaha, Akira
中科院分区：
文献类型：
--
作者：
Yamashita, Yukashi;Ikegami, Taro;Ganaha, Akira
目的本研究的目的是评估第8版美国癌症分期手册联合委员会：为探讨口咽鳞状细胞癌（OPSCC）头颈部组织中p16蛋白过表达与HPV DNA表达的关系，采用新鲜冰冻标本对100例OPSCC患者的组织进行了PCR检测。结果p16阳性34例，p16阴性66例，5年总生存率（OS）分别为73.0%，93.9%和62.2%。与第7版相比，第8版中的操作系统更倾向于与阶段保持一致。从不吸烟或轻度吸烟者的5年OS为96.0%（
PurposeThe aim of this study was to evaluate the 8th edition of the American Joint Committee on Cancer Staging Manual: Head and Neck Section on oropharyngeal squamous cell cancer (OPSCC) and to clarify the relationship between p16 overexpression and the presence of human papillomavirus (HPV) DNA using fresh frozen samples.MethodsSamples from 100 OPSCC patients were analyzed using polymerase chain reaction (PCR) and p16 immunohistochemistry.ResultsFive-year overall survival (OS) was 73.0%, 93.9%, and 62.2% in all, p16-positive (n=34), and p16-negative (n=66) cases, respectively. OS tended to be better aligned with stage in the 8th edition than in the 7th edition. The 5-year OS was 96.0% in never or light smokers (