Modification of expression of the testicular feminization (Tfm) gene of the mouse by a "controlling element" gene.
Modification of expression of the testicular feminization (Tfm) gene of the mouse by a "controlling element" gene.
复制标题
通过“控制元件”基因修改小鼠睾丸女性化（Tfm）基因的表达。
DOI：
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发表时间：
1973
期刊：
影响因子：
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通讯作者：
J. Kan
中科院分区：
文献类型：
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作者：
S. Ohno;L. Christian;B. Attardi;J. Kan
THE X-linked Testicular feminization (Tfm) mutation of the mouse1 gives a totally noninducible phenotype to all the divergent target organs of testosterone in affected Tfm/Y ♀2–7. When all the previous studies are considered together, the nuclear-cytosol receptor protein which shows a higher binding affinity to 5α-dihydrotestosterone (DHT) than to testosterone (TES) emerges as the most likely candidate for the regulatory protein specified by the Tfm locus. Agreement has not been reached as to the nature of the mutational change affecting the receptor protein, for it has variously been reported to be virtually absent3,8,9, present in normal amounts10 and in excess of normal11 in Tfm/Y target cells.
