Vitamin D levels are low in adult patients with sickle cell disease in Jamaica and West Africa.
Vitamin D levels are low in adult patients with sickle cell disease in Jamaica and West Africa.
复制标题
牙买加和西非的成年患者的成年患者的维生素D水平较低。
DOI：
10.1186/2052-1839-14-12
复制
发表时间：
2014
期刊：
影响因子：
--
通讯作者：
Cooper RS
中科院分区：
文献类型：
--
作者：
Tayo BO;Akingbola TS;Salako BL;McKenzie CA;Reid M;Layden J;Osunkwo I;Plange-Rhule J;Luke A;Durazo-Arvizu R;Cooper RS
在美国，与对照组相比，镰状细胞病患者的维生素D水平较低。非裔美国人的平均血清25(OH)D水平也显著低于白人，而25(OH)D在牙买加非裔和西非人中的人口分布与美国白人中相同。这项研究的目的是检查生活在热带地区的成年镰状细胞病患者是否比普通人群减少了25(OH)D。我们分析了在牙买加和西非进行的成人镰状细胞病患者和成人对照人群的研究中收集的储存样本中的血清25(OH)D。在20名牙买加人和50名患有镰状细胞病的西非人的样本中，25(OH)D的平均值分别比对照组低37%和39%。吸收和转化途径的代谢异常可能是镰状细胞病中25(OH)D持续相对缺乏的原因。在镰状细胞疾病负担最高的热带非洲，25(OH)D水平低，值得进一步研究，并有理由进行随机试验以解决补充剂的有效性。
Patients with sickle cell disease in the USA have been noted to have lower levels of vitamin D – measured as 25-hydroxyvitamin D (25(OH)D) – compared to controls. Average serum 25(OH)D levels are also substantially lower in African Americans than whites, while population distributions of 25(OH)D among Jamaicans of African descent and West Africans are the same as among USA whites. The purpose of this study was to examine whether adult patients with sickle cell disease living in tropical regions had reduced 25(OH)D relative to the general population. We analyzed serum 25(OH)D in stored samples collected from studies in Jamaica and West Africa of adult patients with sickle cell disease and adult population controls. In samples of 20 Jamaicans and 50 West Africans with sickle cell disease mean values of 25(OH)D were 37% and 39% lower than controls, respectively. Metabolic abnormalities in the absorption and conversion pathways are possible causes for the consistent relative deficiency of 25(OH)D in sickle cell disease. Low 25(OH)D levels in tropical Africa where the burden of sickle cell disease is highest, deserve further investigation, and a randomized trial is warranted to address efficacy of supplementation.