2,5-Diketopiperazines from the Marine-Derived Fungus Aspergillus fumigatus YK-7
2,5-Diketopiperazines from the Marine-Derived Fungus Aspergillus fumigatus YK-7
复制标题
来自海洋源性真菌烟曲霉 YK-7 的 2,5-二酮哌嗪
DOI：
10.1002/cbdv.201100061
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发表时间：
2012-02-01
影响因子：
2.9
通讯作者：
Hua, Hui-Ming
中科院分区：
文献类型：
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作者：
Wang, Yu;Li, Zhan-Lin;Hua, Hui-Ming
从海洋真菌烟曲霉菌YK-7中分离得到5个新的二酮基哌嗪类化合物，分别为戊烯基环前列腺素B(1)、20-羟基环前列腺素B(2)、9-羟基前列腺素C(3)、6-羟基前列腺素B(4)和螺胶毒素(5)，以及9个已知化合物614。用波谱方法鉴定了它们的结构，并在体外评价了它们对人白血病单核细胞淋巴瘤U937和人前列腺癌PC-3细胞株的抑制作用。化合物10、12和13对U937细胞有明显的生长抑制作用，其IC50值分别为1.8、0.2和0.5mU M。
Five new diketopiperazines, prenylcyclotryprostatin B (1), 20-hydroxycyclotryprostatin B (2), 9-hydroxyfumitremorgin C (3), 6-hydroxytryprostatin B (4), and spirogliotoxin (5), were isolated from the marine-derived fungus Aspergillus fumigatus YK-7, along with nine known compounds, 614. Their structures were elucidated by spectroscopic methods, and their antiproliferative effects on human leukemic monocyte lymphoma U937 and human prostate cancer PC-3 cell lines were assessed in vitro. Compounds 10, 12, and 13 exhibited significant cell growth-inhibitory activities against U937 cell line, with the IC50 values of 1.8, 0.2, and 0.5 mu M, respectively.