A CA2+ Dynamics Model of the STDP Symmetry-to-Asymmetry Transition in the CA1 Pyramidal Cell of the Hippocampus
A CA2+ Dynamics Model of the STDP Symmetry-to-Asymmetry Transition in the CA1 Pyramidal Cell of the Hippocampus
复制标题
海马 CA1 锥体细胞 STDP 对称到不对称转变的 CA2 动力学模型
DOI：
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发表时间：
2008
期刊：
影响因子：
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通讯作者：
B. Graham
中科院分区：
文献类型：
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作者：
Vassilis Cutsuridis;S. Cobb;B. Graham
最近的实验证据表明，CA1锥体神经元的峰值时间依赖可塑性（STDP）分布可以根据沿辐射层（SR）树突的位置分为两种类型：(1)近端辐射层树突以0ms（最大LTP值）为中心的对称STDP分布，在±20ms左右有两个不同的LTD窗口；(2)远端辐射层树突的不对称STDP分布。双曲线应用表明，GABAA对STDP曲线的对称性负责。我们通过计算机模拟研究了近端SR树突中STDP对称到不对称的转变。我们的研究结果表明，从对称到不对称的转变确实是由于GABAA的减少，但模拟的对称STDP剖面以+10ms（而不是0ms）为中心，在-10ms和+40ms（而不是±20ms）有两个不同的LTD尾。模拟的LTD尾强烈依赖于GABAA电导。
Recent experimental evidence has reported that the profiles of spike-timing-dependent plasticity (STDP) in the CA1 pyramidal neuron can be classified into two types depending on the location along the stratum radiatum (SR) dendrite: (1) A symmetric STDP profile centered at 0 ms (largest LTP value) with two distinct LTD windows at about ±20ms in the proximal SR dendrite, and (2) an asymmetric one in the distal SR dendrite. Bicuculline application revealed that GABAA is responsible for the symmetry of the STDP curve. We investigate via computer simulations the STDP symmetry-to-asymmetry transition in the proximal SR dendrite. Our findings indicate the transition from symmetry-to-asymmetry is indeed due to decrease of GABAA, but the simulated symmetrical STDP profile is centered at +10ms (and not at 0ms) with two distinct LTD tails at -10ms and +40ms (and not at ±20ms). The simulated LTD tails are strongly dependent on the GABAA conductance.
影响因子：
2.5
作者：
J. Rubin;R. C. Gerkin;Guoqiang Bi;Carson C. Chow
通讯作者：
J. Rubin;R. C. Gerkin;Guoqiang Bi;Carson C. Chow