Polarization-sensitive optical coherence tomography of invasive basal cell carcinoma
Polarization-sensitive optical coherence tomography of invasive basal cell carcinoma
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DOI：
10.1117/1.1644118
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发表时间：
2004-03-01
影响因子：
3.5
通讯作者：
de Boer, JF
中科院分区：
文献类型：
--
作者：
Strasswimmer, J;Pierce, MC;de Boer, JF
皮肤癌是人类最常见的恶性肿瘤，其中基底细胞癌（BCC）是最常见的类型。侵袭性基底细胞癌与广泛的真皮浸润和胶原蛋白的破坏有关。手术是最常见的治疗方法，但肿瘤边界的识别是一个挑战。偏振敏感光学相干断层扫描（PS-OCT）是一种检测胶原双折射的光学方法。迄今为止，它尚未被用于癌症管理。作为检查OCT在皮肤癌中使用的试点探索性研究的一部分，我们检查了几种肿瘤，这些肿瘤由于其大尺寸和组织学亚型而对外科医生构成挑战。在正常的病灶周围皮肤中，OCT识别表皮和真皮结构; PS-OCT识别真皮双折射。基底细胞癌肿瘤失去了正常的结构，并获得了分叶压迹的外观。PS-OCT发现了皮肤双折射的改变。边缘区域的检查显示从更正常的图像逐渐过渡到坦率的肿瘤。这些结果表明，PS-OCT可以识别区分正常皮肤与肿瘤的特征，并可能有可能指导外科医生治疗侵袭性皮肤癌。(C)2004年，美国光电仪器工程师学会。
Skin cancer is the most common human malignancy, with basal cell carcinoma (BCC) the most frequent type. Aggressive forms of BCC are associated with extensive dermal invasion and destruction of collagen. Surgery is the most common treatment, but identification of tumor borders is a challenge. Polarization-sensitive optical coherence tomography (PS-OCT) is an optical method to examine collagen birefringence. To date, it has not been exploited for cancer management. As part of a pilot exploratory study to examine the use of OCT in skin cancer, we examined several tumors that pose a challenge to the surgeon due to their large size and histological subtype. In normal perilesional skin, OCT identifies epidermal and dermal structure; PS-OCT identified dermal birefringence. In BCC, tumors lost normal structure and gained the appearance of lobular impressions. PS-OCT identified an alteration of dermal birefringence. Examination of a border area revealed a gradual transition from more normal appearing image to frank tumor. These results indicate that PS-OCT can identify features that distinguish normal skin from tumor and may have the potential to guide surgeons in the treatment of aggressive skin cancer. (C) 2004 Society of Photo-Optical Instrumentation Engineers.