Anti-Mullerian hormone levels in serum from human foetuses and children:: pattern and clinical interest
Anti-Mullerian hormone levels in serum from human foetuses and children:: pattern and clinical interest
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DOI：
10.1016/j.mce.2003.09.011
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发表时间：
2003-12-15
影响因子：
4.1
通讯作者：
Noël, M
中科院分区：
文献类型：
--
作者：
Guibourdenche, J;Lucidarme, N;Noël, M
血清抗苗勒氏管激素（AMH）测定已被用于研究性腺发育和性分化异常，但直到最近，它还是基于专业实验室开发的检测方法，不久前，一种灵敏的检测试剂盒（Immunotech-Beckman Coulter）被商业化用于临床。用这种方法，我们建立了胎儿，新生儿和青春期前儿童血清AMH的通常水平，并评估了这种检测的临床价值。AMH测定仅需25穆尔样品，可在3小时内完成。在女性中，AMH在出生后以低水平出现（中位数：4 ng/ml）。在男性中，AMH水平在胎儿期保持稳定（中位数：44.4 ng/ml），在出生后的头几个月达到峰值，中位数为124.7 ng/ml，然后随着个体差异而下降。出生时的脐带血AMH水平可能有助于调查产前怀疑的不明生殖器。在孤立性小阴茎或尿道下裂的儿童中，AMH值降低有利于睾丸功能障碍。当睾丸不能触诊时，血清AMH水平的单一测定可以区分不育症和隐睾。(C)2003爱思唯尔爱尔兰有限公司保留所有权利。
Serum anti-Mullerian hormone (AMH) determination has been used to investigate gonadal development and abnormal sexual differentiation, but until recently, it was based on assays developed by specialized laboratories.A short time ago, a sensitive assay kit was developed commercially (Immunotech-Beckman Coulter) for clinical use. With this method, we established usual levels of serum AMH in fetuses, newborns, and pre-pubertal children, and evaluated the clinical value of this assay. AMH measurement required only 25 mul of sample and could be performed within 3 h. In females, AMH emerged after birth at low levels (median: 4 ng/ml). In males, AMH levels remained stable during fetal life (median: 44.4 ng/ml), peaked in the first months of life to reach a median of 124.7 ng/ml, then fell with wide individual variations. Cord blood AMH levels at birth may be useful to investigate ambiguous genitalia suspected prenatally. In children with isolated microphallus or hypospadias, decreased AMH values are in favor of testis dysfunction. When testes cannot be palpated, a single determination of serum AMH levels can distinguish between anorchia and cryptorchidism. (C) 2003 Elsevier Ireland Ltd. All rights reserved.