Antitumor agents .171. Cytotoxicities of lobatosides B, C, D, and E, cyclic bisdesmosides isolated from Actinostemma lobatum Maxim
Antitumor agents .171. Cytotoxicities of lobatosides B, C, D, and E, cyclic bisdesmosides isolated from Actinostemma lobatum Maxim
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DOI：
10.1016/s0960-894x(96)00522-7
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发表时间：
1996-12-03
影响因子：
2.7
通讯作者：
Lee, KH
中科院分区：
文献类型：
--
作者：
Fujioka, T;Kashiwada, Y;Lee, KH
评价了从裂叶放线菌中分离的裂叶皂苷B-E和放线梗皂苷B-F对一组约60种人癌细胞系的细胞毒性。Lobatosides B-E（1-4）对所有肿瘤细胞系均具有细胞毒性（GI（50）小于或等于1 × 10（-4）M）; 4显示出强的细胞毒性，尤其是对A-549、SK-MEL-5和SW-620细胞系，GI（50）值分别为0.14、0.14和0.36 μ M。版权所有（C）1996 Elsevier Science Ltd
Cytotoxicities for lobatosides B-E and actinostemmosides B-F, isolated from Actinostemma lobatum, were evaluated against a panel of ca 60 human cancer cell lines. Lobatosides B-E (1-4) were cytotoxic (GI(50) less than or equal to 1 x 10(-4)M) against all tumor cell Lines; 4 showed potent cytotoxicity especially against A-549, SK-MEL-5, and SW-620 cell lines with GI(50) values of 0.14, 0.14, and 0.36 mu M, respectively. Copyright (C) 1996 Elsevier Science Ltd