Studies on the mechanism of benzene toxicity.
Studies on the mechanism of benzene toxicity.
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DOI：
10.1289/ehp.898231
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发表时间：
1989-07
影响因子：
10.4
通讯作者：
中科院分区：
文献类型：
--
作者：
使用Lee等人的~(59)Fe摄取法。结果表明，ip苯、对苯二酚、对苯二酚和邻苯二醛可抑制雌性小鼠的红细胞生成。甲苯可防止苯的影响。苯酚与对苯二酚或邻苯二酚合用时，毒性大大增加。在减少铁摄取方面，最有效的代谢物组合是对苯二酚和邻苯二甲醛。我们还表明，用苯处理动物会导致骨髓DNA加合物的形成，这是通过~(32)P后标记技术测得的。
Using the 59Fe uptake method of Lee et al. it was shown that erythropoiesis in female mice was inhibited following IP administration of benzene, hydroquinone, p-benzoquinone, and muconaldehyde. Toluene protected against the effects of benzene. Coadministration of phenol plus either hydroquinone or catechol resulted in greatly increased toxicity. The combination of metabolites most effective in reducing iron uptake was hydroquinone plus muconaldehyde. We have also shown that treating animals with benzene leads to the formation of adducts of bone marrow DNA as measured by the 32P-postlabeling technique.