Efficacy of periodontal treatment on glycaemic control in diabetic patients: A meta-analysis of interventional studies
Efficacy of periodontal treatment on glycaemic control in diabetic patients: A meta-analysis of interventional studies
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DOI：
10.1016/j.diabet.2008.03.006
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发表时间：
2008-11-01
影响因子：
7.2
通讯作者：
Sixou, M.
中科院分区：
文献类型：
--
作者：
Darre, L.;Vergnes, J. -N.;Sixou, M.
目的。 - 越来越多的证据表明牙周病可能会促进糖尿病及其并发症的发生或加重。为了调查这个问题，我们对牙周治疗对糖尿病患者血糖控制的影响进行了荟萃分析。方法。 - 使用七个数据库（Medline、EMBASE、LILACS、The Cochrane Library、Pascal、IADR Abstracts 和 Current Contents）进行文献检索，无语言限制。我们遵循 QUOROM 推荐的标准来提高干预研究荟萃分析的报告质量。结果。 - 本系统评价纳入了 25 项研究，共涉及 976 名受试者。其中，9 项研究为对照试验，共涉及 485 名患者，并纳入荟萃分析。牙周病治疗后 HbA(1c) 的标准化平均差异为 0.46 (95% CI: 0.11, 0.82)。这些发现表明牙周治疗可导致 HbA(1c) 水平显着降低 0.79% (95% CI: 0.19, 1.40)。结论。 - 本荟萃分析代表了迄今为止解决该问题的最佳信息，并表明牙周治疗可以改善血糖控制。然而，这些结果需要谨慎看待，因为这些结果缺乏稳健性，并且其中一些研究的设计存在缺陷。具有足够统计能力的随机对照试验将有助于证实该荟萃分析的结果。 (C) 2008 Elsevier Masson SAS。版权所有。
Aim. - There is growing evidence that periodontal disease may favour the incidence or aggravation of diabetes and its complications. To investigate the issue, we conducted a meta-analysis of the effect of periodontal therapy on glycaemic control in diabetic patients.Methods. - A literature search was carried Out using seven databases (Medline, EMBASE, LILACS, The Cochrane Library, Pascal, IADR Abstracts and Current Contents), with no language restrictions. We followed the QUOROM-recommended standards for improving the quality of reporting meta-analyses of interventional studies.Results. - Twenty-five studies, involving 976 subjects if together, were included in the present systematic review. Of these, nine Studies, involving a total of 485 patients, were controlled trials and were included in the meta-analysis. The standardized mean difference in HbA(1c) with the treatment of periodontal disease was 0.46 (95% CI: 0.11, 0.82). These findings suggest that periodontal treatment could lead to a significant 0.79% (95% CI: 0.19, 1.40) reduction in HbA(1c) level.Conclusion. - The present meta-analysis represents the best information available to date that addresses this issue, and suggests that periodontal treatment could improve glycaemic control. Nevertheless, these results need to be viewed with caution because of a lack of robustness, and deficiencies in the design of some of the studies included. A randomized controlled trial with sufficient statistical power would help to confirm the results of this meta-analysis. (C) 2008 Elsevier Masson SAS. All rights reserved.