Striatal dopamine D2/3 receptor availability increases after long-term bariatric surgery-induced weight loss
Striatal dopamine D2/3 receptor availability increases after long-term bariatric surgery-induced weight loss
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DOI：
10.1016/j.euroneuro.2016.04.009
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发表时间：
2016-07-01
影响因子：
5.6
通讯作者：
Serlie, Mireille J.
中科院分区：
文献类型：
--
作者：
van der Zwaal, Esther M.;de Weijer, Barbara A.;Serlie, Mireille J.
在几项研究中，与瘦对照组相比，肥胖受试者的纹状体多巴胺D-2/3受体（D2/3R）可用性降低。这是否是一个可逆的现象仍然不确定。我们先前确定了Roux-en-Y胃旁路手术（RYGB）对20名病态肥胖女性纹状体D2/3R可用性的短期影响（使用[I-123]IBZM SPECT）。纹状体D2/3R的可用性较低相比，对照组在基线，并保持不变，6周后，尽管显着的体重loss.To确定是否长期减肥手术引起的体重减轻正常化纹状体D2/3R结合，我们重复纹状体D2/3R结合测量至少2年后，RYGB在14个受试者的原始队列。此外，我们评估了身体成分、饮食行为和空腹血浆瘦素、生长激素释放肽、胰岛素和葡萄糖水平的长期变化，平均体重指数从46 +/- 7 kg/m2下降到32 +/- 6 kg/m2，伴随着纹状体D2/3R可用性的显著增加（p=0.031）。与年龄匹配的对照组相比，纹状体D2/3R的可用性仍然显著降低（BMI 22 +/- 2 kg/m2; p=0.01）。纹状体D2/3R可用性的变化与体重/脂肪、胰岛素敏感性、生长激素释放肽或瘦素水平的变化无关。饮食行为问卷的分数提高和一般食物渴望的焦虑状态的变化显示了与纹状体D2/3R可用性变化的边缘显著相关性。这些发现表明，长期减肥手术诱导的体重减轻后，纹状体D2/3R可用性增加，这表明肥胖症患者D2/3R可用性降低是一种可逆现象。(C)2016年Elsevier BV和ECNP。All rights reserved.
In several studies reduced striatal dopamine D-2/3 receptor (D2/3R) availability was reported in obese subjects compared to lean controls. Whether this is a reversible phenomenon remained uncertain. We previously determined the short-term effect of Roux-en-Y gastric bypass surgery (RYGB) on striatal D2/3R availability (using [I-123]IBZM SPECT) in 20 morbidly obese women. Striatal D2/3R availability was lower compared to controls at baseline, and remained unaltered after 6 weeks, despite significant weight loss.To determine whether long-term bariatric surgery-induced weight loss normalizes striatal D2/3R binding, we repeated striatal D2/3R binding measurements at least 2 years after RYGB in 14 subjects of the original cohort. In addition, we assessed long-term changes in body composition, eating behavior and fasting plasma levels of leptin, ghrelin, insulin and glucose.Mean body mass index declined from 46 +/- 7 kg/m(2) to 32 +/- 6 kg/m(2), which was accompanied by a significant increase in striatal D2/3R availability (p=0.031). Striatal D2/3R availability remained significantly reduced compared to the age-matched controls (BMI 22 +/- 2 kg/m(2); p=0.01). Changes in striatal D2/3R availability did not correlate with changes in body weight/fat, insulin sensitivity, ghrelin or leptin levels. Scores on eating behavior questionnaires improved and changes in the General Food Craving Questionnaire-State showed a borderline significant correlation with changes in striatal D2/3R availability.These findings show that striatal D2/3R availability increases after long-term bariatric-surgery induced weight loss, suggesting that reduced D2/3R availability in obesity is a reversible phenomenon. (C) 2016 Elsevier B.V. and ECNP. All rights reserved.