Physical Exercise Improves Cognitive Function in Older Adults with Stage 3?4 Chronic Kidney Disease: A Randomized Controlled Trial
Physical Exercise Improves Cognitive Function in Older Adults with Stage 3?4 Chronic Kidney Disease: A Randomized Controlled Trial
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体育锻炼可改善患有 3-4 期慢性肾病的老年人的认知功能：一项随机对照试验
DOI：
10.1159/000520230
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发表时间：
2021
影响因子：
4.2
通讯作者：
Tominaga Naoto
中科院分区：
文献类型：
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作者：
Otobe Yuhei;Yamada Minoru;Hiraki Koji;Onari Satoshi;Taki Yasuhiro;Sumi Hirofumi;Hachisuka Rina;Han Wei;Takahashi Masaki;Suzuki Mizue;Kimura Yosuke;Koyama Shingo;Masuda Hiroaki;Shibagaki Yugo;Tominaga Naoto
引言：慢性肾脏病（CKD）患者发生认知障碍或痴呆的概率高于无CKD患者。体育锻炼对认知功能的有益影响在一般老年人群中是已知的，但需要更多的研究在老年人CKD.Methods：81例门诊患者（年龄≥65岁）与CKD阶段G3-G4进行了资格评估。其中，60例患者接受随机化（单中心、非盲和分层），53例接受分配的干预（exercisen= 27，controln= 26）。运动组的患者每周在我们的设施进行一次集体运动训练，每周两次或更多次在家里进行独立运动，持续24周。对照组给予一般护理。一般和特定的认知功能（记忆，注意力，执行，和口头）进行了测量，并在基线和在24周的随访访视的分数的差异进行了评估之间的2 groups.Results：44例患者完成了后续行动，在24周（exercisen= 23，controln= 21）。运动组的患者在韦氏记忆量表-修订的逻辑记忆延迟回忆中表现出显著更大的变化（运动效应：2.82，95%CI：0.46- 5.19，p = 0.03），即刻和延迟回忆结论：24周的运动干预可显著改善老年慢性肾脏病透析前患者的记忆功能。这项随机对照试验表明，体育锻炼是预防这些患者认知能力下降的一种有用的非药物策略。
Introduction:Patients with chronic kidney disease (CKD) exhibit a higher probability of having cognitive impairment or dementia than those without CKD. The beneficial effects of physical exercise on cognitive function are known in the general older population, but more research is required in older adults with CKD.Methods:Eighty-one outpatients (aged ≥65 years) with CKD stage G3–G4 were assessed for eligibility. Among them, 60 were randomized (single-center, unblinded, and stratified) and 53 received the allocated intervention (exercisen= 27, controln= 26). Patients in the exercise group undertook group-exercise training at our facility once weekly and independent exercises at home twice weekly or more, for 24 weeks. Patients in the control group received general care. General and specific cognitive functions (memory, attention, executive, and verbal) were measured, and differences in their scores at baseline and at the 24-week follow-up visit were assessed between the 2 groups.Results:Forty-four patients completed the follow-up at 24 weeks (exercisen= 23, controln= 21). Patients in the exercise group showed significantly greater changes in Wechsler Memory Scale-Revised Logical Memory delayed recall (exercise effect: 2.82, 95% CI: 0.46–5.19,p= 0.03), and immediate and delayed recall (exercise effect: 5.97, 95% CI: 1.13–10.81,p= 0.02) scores than those in the control group.Conclusions:The 24-week exercise intervention significantly improved the memory function in older adults with pre-dialysis CKD. This randomized controlled trial suggests that physical exercise is a useful nonpharmacological strategy for preventing cognitive decline in these patients.