A review of hydrogen sulfide (H(2)S) donors: Chemistry and potential therapeutic applications.
A review of hydrogen sulfide (H(2)S) donors: Chemistry and potential therapeutic applications.
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DOI：
10.1016/j.bcp.2017.11.014
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发表时间：
2018-03
影响因子：
5.8
通讯作者：
Matson JB
中科院分区：
文献类型：
--
作者：
Powell CR;Dillon KM;Matson JB
硫化氢（H2S）是一种普遍存在的小的气体信号分子，在许多生理过程中发挥重要作用，并加入一氧化氮和一氧化碳的气体递质的组中的信号剂。H2S的内源浓度通常较低，因此很难辨别精确的生物学功能。因此，探测H2S的生理作用是通过在细胞和动物研究中外源性递送气体来辅助的。这种对H2S外源性来源的需求为化学家开发化学工具以促进在生物条件下研究H2S提供了独特的挑战。响应于释放H2S的特定触发剂而降解的化合物（称为H2S供体）包括多种官能团和递送系统，其中一些模拟响应于特定的生物相关条件而严格控制的内源性产生。本文综述了各种H2S供体系统分类的H2S释放触发器，以及他们的H2S释放概况，副产品，和潜在的治疗应用。
Hydrogen sulfide (H2S) is a ubiquitous small gaseous signaling molecule, playing an important role in many physiological processes and joining nitric oxide and carbon monoxide in the group of signaling agents termed gasotransmitters. Endogenous concentrations of H2S are generally low, making it difficult to discern precise biological functions. As such, probing the physiological roles of H2S is aided by exogenous delivery of the gas in cell and animal studies. This need for an exogenous source of H2S provides a unique challenge for chemists to develop chemical tools that facilitate the study of H2S under biological conditions. Compounds that degrade in response to a specific trigger to release H2S, termed H2S donors, include a wide variety of functional groups and delivery systems, some of which mimic the tightly controlled endogenous production in response to specific, biologically relevant conditions. This review examines a variety of H2S donor systems classified by their H2S-releasing trigger as well as their H2S release profiles, byproducts, and potential therapeutic applications.
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影响因子：
6.1
作者：
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通讯作者：
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