Effects of partial circadian adjustments on sleep and vigilance quality during simulated night work
Effects of partial circadian adjustments on sleep and vigilance quality during simulated night work
复制标题
DOI：
10.1111/j.1365-2869.2012.00998.x
复制
发表时间：
2012-08-01
影响因子：
4.4
通讯作者：
Dumont, Marie
中科院分区：
文献类型：
--
作者：
Chapdelaine, Simon;Paquet, Jean;Dumont, Marie
在大多数情况下，不建议夜班工人进行完全的昼夜节律调整。经过彻底的调整，工人在回到白天活动的时间表时，会经历昼夜节律失调，导致重复的昼夜节律相移和内部不同步。出于这个原因，部分昼夜节律调整被认为是稳定夜班工人内部昼夜节律的一个很好的妥协。然而，改善睡眠和警觉性质量所必需的部分昼夜节律调整的程度仍然是一个有争议的问题。在这项研究中，在实验室模拟夜间工作中评估了小但统计上显著的部分昼夜节律调整对睡眠和警觉性质量的影响，以确定它们是否也具有临床意义。通过相位延迟或相位提前获得的部分调整不仅可以通过昏暗光线下唾液褪黑素发作的相移来量化，还可以通过模拟夜间工作中采用的睡眠-觉醒周期中褪黑素产生的事件的重叠来量化。对白天睡眠和夜间警觉性质量的影响不大。然而，他们认为，即使是通过阶段延迟进行的微小调整也可能减少睡眠债务的积累，而提前策略则可以提高夜间工作时的主观警觉性和情绪。此外，绝对相移，无论是提前还是延迟，都与夜班期间主观警觉性和情绪的改善有关。这些策略需要在现场进行测试，以确定它们是否可以适应现实情况，并为夜班工人提供有效的支持。
In most situations, complete circadian adjustment is not recommended for night workers. With complete adjustment, workers experience circadian misalignment when returning on a day-active schedule, causing repeated circadian phase shifts and internal desynchrony. For this reason, partial circadian realignment was proposed as a good compromise to stabilize internal circadian rhythms in night shift workers. However, the extent of partial circadian adjustment necessary to improve sleep and vigilance quality is still a matter of debate. In this study, the effects of small but statistically significant partial circadian adjustments on sleep and vigilance quality were assessed in a laboratory simulation of night work to determine whether they were also of clinical significance. Partial adjustments obtained by phase delay or by phase advance were quantified not only by the phase shift of dim light salivary melatonin onset, but also by the overlap of the episode of melatonin production with the sleepwake cycle adopted during simulated night work. The effects on daytime sleep and night-time vigilance quality were modest. However, they suggest that even small adjustments by phase delay may decrease the accumulation of sleep debt, whereas the advance strategy improves subjective alertness and mood during night work. Furthermore, absolute phase shifts, by advance or by delay, were associated with improved subjective alertness and mood during the night shift. These strategies need to be tested in the field, to determine whether they can be adapted to real-life situations and provide effective support to night workers.