Sodium and potassium movement in the excised rat aorta.
Sodium and potassium movement in the excised rat aorta.
复制标题
离体大鼠主动脉中钠和钾的运动。
DOI：
10.1152/ajplegacy.1960.199.1.28
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发表时间：
1960
期刊：
影响因子：
--
通讯作者：
D. Bohr
中科院分区：
文献类型：
--
作者：
O. Dawkins;D. Bohr
当大鼠的主动脉被切下并放入Krebs溶液中时，在最初的15秒内，它失去了超过三分之二的钾，并获得了大约等量的钠。如果将主动脉置于大鼠血浆而不是克雷布斯溶液中，也会发生类似的变化。当用克雷布斯溶液灌注整个大鼠时，主动脉电解质组成不会发生这些快速变化。它的结论是，在处理涉及去除主动脉的细胞膜屏障被改变，以这样一种方式，他们不再保持这些阳离子的正常跨膜梯度。在浴中2分钟后，主动脉中的钾逐渐增加，其钠减少，表明细胞膜已恢复其作为屏障的特性，并能够维持由主动转运系统建立的钠和钾梯度。
When the rat aorta is excised and placed in a bath of Krebs' solution it loses over two-thirds of its potassium and gains roughly an equivalent amount of sodium within the first 15 seconds. If the aorta is placed in rat plasma instead of Krebs' solution, a similar change occurs. These rapid changes in aorta electrolyte composition do not occur when the whole rat is perfused with Krebs' solution. It is concluded that in the handling involved in the removal of the aorta its cell membrane barriers are altered in such a way that they no longer maintain the normal transmembrane gradients of these cations. After 2 minutes in the bath the potassium in the aorta gradually increases and its sodium decreases suggesting that the cell membrane has regained its characteristics as a barrier and is capable of maintaining sodium and potassium gradients established by an active transport system.