Concentrations of antibodies in paired maternal and infant sera: relationship to IgG subclass.
Concentrations of antibodies in paired maternal and infant sera: relationship to IgG subclass.
复制标题
配对母体和婴儿血清中抗体的浓度：与 IgG 亚类的关系。
DOI：
10.1016/s0022-3476(87)80268-8
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发表时间：
1987
期刊：
影响因子：
--
通讯作者：
Shackelford,PG
中科院分区：
文献类型：
--
作者：
Einhorn,MS;Granoff,DM;Nahm,MH;Quinn,A;Shackelford,PG
先前比较脐带和母体血清中的免疫球蛋白亚类浓度的研究表明，免疫球蛋白G1比免疫球蛋白G2在更大程度上通过胎盘转运。我们研究的目的是研究IgG1和IgG2的转运与相对局限于特定亚类的特异性抗体的转运之间的关系，即IgG1或IgG2。对30例母血和脐血进行了血清总IgG1、IgG2、抗破伤风类毒素(TT)和抗A组链球菌糖类抗体(GAC)的检测。以前的研究表明，成人中的抗TT主要是IgG1，而抗GAC主要是IgG2。脐血/母血平均浓度比值分别为1.77±0.56和1.93±0.67，与IgG2和抗-GAC分别为0.99±0.39和1.01±0.45相比，差异有统计学意义(P=0.0001)。通过检测抗b型流感嗜血杆菌衣壳多糖的IgG1和IgG2抗体证实了脐血/母体抗体浓度比的差异，IgG1-抗Hib多糖组的脐血/母体浓度比显著高于IgG2-抗Hib多糖组(2.23±0.83比0.94±0.49，P=0.01)。这些结果表明，胎盘对免疫球蛋白抗体的转运与其亚类组成有关。
Previous studies comparing IgG subclass concentrations in cord and maternal sera have indicated that IgG1is transported across the placenta to a greater extent than is IgG2. The purpose of our study was to examine the relationship between the transport of IgG1and IgG2and the transport of specific antibodies that are relatively restricted to a particular subclass, either IgG1or IgG2. The concentrations of total serum IgG1and IgG2and those of IgG-anti-tetanus toxoid (TT) and anti-group A streptococcal carbohydrate (GAC) were measured in 30 paired maternal and cord sera. Previous studies have shown that anti-TT in adults is predominantly IgG1, whereas anti-GAC is predominantly IgG2. The mean cord/maternal concentration ratios of IgG1and anti-TT were similar (1.77±0.56 and 1.93±0.67, respectively), but differed significantly (P=0.0001) from those of IgG2and anti-GAC (0.99±0.39 and 1.01±0.45, respectively). We confirmed the difference in cord/maternal concentration ratios of IgG1and IgG2antibodies by measuring, IgG1and IgG2antibodies specific forHaemophilus influenzaetype b capsular polysaccharide; the mean cord/maternal concentration ratio of IgG1-anti-Hib PS was significantly higher than that of IgG2-anti-Hib PS (2.23±0.83 compared with 0.94±0.49, P=0.01). These results indicate that placental transport of IgG antibodies is related to their subclass composition.