ROLE OF NITRIC-OXIDE SYNTHESIS IN MACROPHAGE ANTIMICROBIAL ACTIVITY
ROLE OF NITRIC-OXIDE SYNTHESIS IN MACROPHAGE ANTIMICROBIAL ACTIVITY
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DOI：
10.1016/0952-7915(91)90079-g
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发表时间：
1991-02-01
影响因子：
7
通讯作者：
HIBBS, JB
中科院分区：
文献类型：
--
作者：
NATHAN, CF;HIBBS, JB
过去5年的研究表明，小鼠巨噬细胞的免疫激活诱导一氧化氮合酶的活性，该酶氧化L-精氨酸的胍基氮，产生瓜氨酸和活性自由基一氧化氮。 对巨噬细胞中这一通路的生物化学和免疫调节的综述提供了评估其效应器功能的背景。 在过去的2年中发表的报告表明，NO的合成介导了小鼠巨噬细胞对一些真菌，蠕虫，原生动物和细菌病原体的抗菌活性。
Research over the past 5 years has demonstrated that immunologic activation of mouse macrophages induces the activity of nitric oxide synthase, which oxidizes a guanidino nitrogen of L-arginine, yielding citrulline and the reactive radical, nitric oxide. A review of the biochemistry and immunologic regulation of this pathway in macrophages provides a backdrop against which to evaluate its effector functions. Reports published in the past 2 years suggest that synthesis of NO mediates much of the antimicrobial activity of mouse macrophages against some fungal, helminthic, protozoal and bacterial pathogens.