Environmental Circadian Disruption Worsens Neurologic Impairment and Inhibits Hippocampal Neurogenesis in Adult Rats After Traumatic Brain Injury.
Environmental Circadian Disruption Worsens Neurologic Impairment and Inhibits Hippocampal Neurogenesis in Adult Rats After Traumatic Brain Injury.
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环境昼夜节律紊乱会加剧脑外伤后成年大鼠的神经损伤并抑制海马神经发生
DOI：
10.1007/s10571-015-0295-2
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发表时间：
2016-10
影响因子：
4
通讯作者：
Wang J
中科院分区：
文献类型：
--
作者：
Li D;Ma S;Guo D;Cheng T;Li H;Tian Y;Li J;Guan F;Yang B;Wang J
昼夜节律调节许多生理过程和行为。因此，它们的干扰会对人类和动物造成各种潜在的不利影响。研究发现，持续光照引起的昼夜节律紊乱会在脑损伤后产生病理生理后果。然而，导致更严重的神经生理过程损伤和中断的潜在机制还不是很清楚。在这里，我们评估了持续光照对创伤性脑损伤(TBI)后大鼠神经行为损害和神经元存活的影响。将60只成年雄性SD大鼠复制成颅脑损伤后体重下降模型，然后暴露于标准的12/12小时光/暗周期或持续24小时的光/光周期，共14天。我们的结果表明，脑损伤后持续14天的光照显著恶化了感觉运动和认知障碍，这与体重下降、水和食物摄入受损、皮质损伤体积增加和神经元存活率下降有关。此外，环境昼夜节律的干扰抑制了脑损伤模型大鼠的细胞增殖和新生细胞存活，并减少了未成熟细胞的产生。我们得出结论，持续光照引起的昼夜节律紊乱会加重成年脑创伤大鼠的组织学和神经行为损伤，并抑制神经发生。我们的新发现表明，住院的脑外伤患者应减少光暴露，重建昼夜节律，维持昼夜节律的药物和策略将提供一种新的治疗选择。
Circadian rhythms modulate many physiologic processes and behaviors. Therefore, their disruption causes a variety of potential adverse effects in humans and animals. Circadian disruption induced by constant light exposure has been discovered to produce pathophysiologic consequences after brain injury. However, the underlying mechanisms that lead to more severe impairment and disruption of neurophysiologic processes are not well understood. Here, we evaluated the effect of constant light exposure on the neurobehavioral impairment and survival of neurons in rats after traumatic brain injury (TBI). Sixty adult male Sprague–Dawley rats were subjected to a weight-drop model of TBI and then exposed to either a standard 12-/12-h light/dark cycle or a constant 24-h light/light cycle for 14 days. Our results showed that 14 days of constant light exposure after TBI significantly worsened the sensorimotor and cognitive deficits, which were associated with decreased body weight, impaired water and food intake, increased cortical lesion volume, and decreased neuronal survival. Furthermore, environmental circadian disruption inhibited cell proliferation and newborn cell survival and decreased immature cell production in rats subjected to the TBI model. We conclude that circadian disruption induced by constant light exposure worsens histologic and neurobehavioral impairment and inhibits neurogenesis in adult TBI rats. Our novel findings suggest that light exposure should be decreased and circadian rhythm reestablished in hospitalized TBI patients and that drugs and strategies that maintain circadian rhythm would offer a novel therapeutic option.