Ion collision cross section measurements in Fourier transform-based mass analyzers
Ion collision cross section measurements in Fourier transform-based mass analyzers
复制标题
基于傅里叶变换的质量分析仪中的离子碰撞截面测量
作者：
Li Dayu;Tang Yang;Xu Wei
随着分子结构分析需求的不断增加，人们开发了多种方法来测量基于傅里叶变换 (FT) 的质量分析仪中的离子碰撞截面。特别是2012年以来的近三年，在傅里叶变换离子回旋共振（FT-ICR）细胞中实现了获得生物分子碰撞截面的方法。此外，已经针对轨道阱和四极离子阱实现或提出了类似的方法。该技术为基于 FT 的质量分析仪增加了新的离子结构分析功能。通过提供互补的离子结构信息，它可以与串联质谱和离子迁移谱技术一起使用。尽管仍然存在许多问题和挑战，但该技术有可能大大增强质谱仪的离子结构分析能力，并为化学家和生物化学家提供新工具。
With the increasing demands of molecular structure analysis, several methods have been developed to measure ion collision cross sections within Fourier transform (FT) based mass analyzers. Particularly in the recent three years since 2012, the method of obtaining biomolecule collision cross sections was achieved in Fourier transform ion cyclotron resonance (FT-ICR) cells. Furthermore, similar methods have been realized or proposed for orbitraps and quadrupole ion traps. This technique adds a new ion structure analysis capability to FT-based mass analyzers. By providing complementary ion structure information, it could be used together with tandem mass spectrometry and ion mobility spectroscopy techniques. Although many questions and challenges remain, this technique potentially would greatly enhance the ion structure analysis capability of a mass spectrometer, and provide a new tool for chemists and biochemists.