Transperitoneal Oxygenation with Fluorocarbons
Transperitoneal Oxygenation with Fluorocarbons
复制标题
碳氟化合物经腹膜给氧
DOI：
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发表时间：
1986
影响因子：
5.7
通讯作者：
A. Trouwborst
中科院分区：
文献类型：
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作者：
J. Klein;N. Faithfull;P. Salt;A. Trouwborst
本工作研究了全氟碳载氧血液替代物FC43对低氧大鼠腹膜灌流过程中动脉氧合的改善作用。Wistar大鼠分为三组，每组6只，用低氧混合气体进行呼吸，以获得大约55 mm Hg的动脉血氧分压(PaO2)。两组均以含氧FC43或明胶溶液海马可进行20mlmin的腹膜灌流。第三组是假手术，但没有灌流。两组动脉血氧分压均显著升高，FC43组升高更明显。只有FC43组的二氧化碳张力显著降低。FC43组和Haemaccel组的动脉血氧饱和度在15分钟后显著升高，60分钟后显著升高。FC43可提供15%以上的氧耗量。
This work investigated the improvement of arterial oxygenation in hypoxic rats during peritoneal perfusion with the oxygen-carrying perfluorocarbon blood substitute FC43. Three groups of six Wistar rats were ventilated with hypoxic gas mixtures to obtain an arterial oxygen tension (PaO2) of approximately 55 mm Hg. Two groups were subjected to peritoneal perfusion at 20 mllmin with oxygenated FC43or the gelatine solution Haemaccel. A third group was sham operated but not perfused. In both perfused groups PaO2 increased significantly, more so in the FC43 group. Carbon dioxide tensions significantly decreased only in the FC43 group. Significant increases in arterial oxyhemoglobin saturation were seen after 15 min in the FC43 group and after 60 min in the Haemaccel group. More than 15% of oxygen consumption could be delivered by peritoneal perfusion with FC43.