Changes in Blood Hormone Levels during the Immune Response
Changes in Blood Hormone Levels during the Immune Response
复制标题
免疫反应期间血液激素水平的变化
DOI：
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发表时间：
1975
期刊：
影响因子：
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通讯作者：
J. Müller
中科院分区：
文献类型：
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作者：
H. Besedovsky;E. Sorkin;M. Keller;J. Müller
将三种不同的抗原注射到大鼠或小鼠体内，在几天的时间内，血清皮质酮水平增加约三倍，同时甲状腺素下降（大鼠）。鉴于已知的糖皮质激素的免疫抑制作用，有可能在免疫反应期间引起的内分泌变化可以显著调节免疫反应的后续特征，即强度、持续时间和淋巴样细胞增殖，然而，需要确定更完整的激素变化模式及其原因。这些发现虽然是初步的，但足以说明免疫反应期间激素变化的时间模式，这在免疫调节中可能是重要的。
Summary Injection of three different antigens into rats or mice led in the course of several days to about a threefold increase in serum corticosterone levels and concommitantly to a decrease in thyroxine (rats). In view of the known immuno-suppressive effect of the glucocorticoids the possibility is considered that the endocrine changes induced during the immune response could significantly modulate the subsequent character of the immune response, e.i. magnitude, duration and lymphoid cell proliferation, however, a more complete pattern of hormonal variations and their cause needs to be established. These findings while admittedly preliminary, suffice to provide an indication of a temporal pattern of hormonal change during the immune response which could be important in immunoregulation.